|
| A 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran-based near-infrared fluorescence probe for the detection of hydrogen sulfide and imaging of living cells |
| Author Name | Affiliation | E-mail | | ZHANG Linfang | School of Chemistry and Chemical Engineering, Yili Normal University, Yining, Xinjiang 835000, China | | | YIN Wenzhu | Institute of Veterinary Immunology & Engineering, National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China | | | YIN Gui | School of Chemistry and Chemical Engineering, Yili Normal University, Yining, Xinjiang 835000, China
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China | yingui@nju.edu.cn |
|
| Abstract: Using 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) as a near-infrared fluorescent chromophore, we designed and synthesized a TCF-based fluorescent probe TCF-NS by introducing 2,4-dinitrophenyl ether as the recognized site for H2S. The probe TCF-NS displayed a rapid-response fluorescent against H2S with high sensitivity and selection but had no significant fluorescence response to other biothiols. Furthermore, TCF-NS was applied to sense H2S in living cells successfully with minimized cytotoxicity and a large Stokes shift. |
| Keywords: hydrogen sulfide near-infrared fluorescence probe cell imaging |
| Hits: 66 |
| Download times: 12 |
| ZHANG Linfang,YIN Wenzhu,YIN Gui.A 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran-based near-infrared fluorescence probe for the detection of hydrogen sulfide and imaging of living cells[J].Chinese Journal of Inorganic Chemistry,2025,41(3):540-548. |
| View Full Text View/Add Comment Download reader |
|
|
|
|
|
|
|
|
