| 手性无机纳米催化剂在电化学与类酶生物传感中的应用 | |
| Chiral inorganic nanocatalysts for electrochemical and enzyme-mimicked biosensing | |
| 摘要: 近年来，手性无机纳米材料在传感、催化、生物医学和光子学等领域显现出了巨大应用潜力。具有本征手性结构的等离激元纳米材料因其等离激元光学特性与手性的精妙融合，展现出了高度可调且极为优越的手性光学特质。近年来，手性无机纳米材料在合成及结构调控方面取得了大量成果，有力地推动了其在众多新兴技术领域广泛应用的进程，从而衍生出大量前所未有的机遇与可能。本文介绍了手性无机纳米材料在生物传感方面的最新研究进展，其中特别关注了电化学和酶模拟催化方法。首先本文回顾了手性纳米催化剂的基本原理，包括手性配体诱导机制和固有手性纳米结构。其次，文中分别系统地介绍了手性纳米催化剂在电化学和酶模拟催化生物传感中的应用。最后，展望了将手性纳米探针用于新兴生物传感应用的挑战和机遇。通过合理设计手性纳米探针，可以实现单分子水平的灵敏度和分辨率不断提高的生物传感，这将大大促进许多新兴跨学科领域的传感应用。 | |
| 关键词: 手性无机纳米材料 手性等离激元 电化学生物传感 模拟酶生物传感 不对称纳米催化 | |
| 基金项目: 国家自然科学基金(No.22174104，22472119，22405195)和江苏省自然科学基金(No.BK20240448)资助。 | |
| Abstract: In recent years, chiral inorganic nanomaterials have become promising candidates for applications in sensing, catalysis, biomedicine, and photonics. Plasmonic nanomaterials with an intrinsic chiral structure exhibit intriguing geometry- dependent optical chirality, which benefits the combination of plasmonic characteristics with chirality. Recent advances in the biomolecule-directed geometric control of intrinsically chiral plasmonic nanomaterials have further provided great opportunities for their widespread applications in many emerging technological areas. In this review, we present the recent progress in biosensing using chiral inorganic nanomaterials, with a particular focus on electrochemical and enzyme-mimicking catalytic approaches. This paper commences with a review of the basic tenets underlying chiral nanocatalysts, incorporating the chiral ligand - induced mechanism and the architectures of intrinsically chiral nanostructures. Additionally, it methodically expounds upon the applications of chiral nanocatalysts in the realms of electrochemical biosensing and enzyme-mimicking catalytic biosensing respectively. Conclusively, it proffers a prospective view of the hurdles and prospects that accompany the deployment of chiral nanoprobes for nascent biosensing applications. By rational design of the chiral nanoprobes, it is envisioned that biosensing with increasing sensitivity and resolution toward the single-molecule level can be achieved, which will substantially promote sensing applications in many emerging interdisciplinary areas. | |
| Keywords: chiral inorganic nanomaterial chiral plasmonic electrochemical biosensing enzyme-mimicked biosensing asymmetric nanocatalysis | |
| 投稿时间：2024-11-13 修订日期：2024-12-11 | |
| 摘要点击次数: 787 | |
| 全文下载次数: 228 | |
| 刘闯,孙丽超,张庆丰.手性无机纳米催化剂在电化学与类酶生物传感中的应用[J].无机化学学报,2025,41(1):59-78. | |
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