| 基于多齿席夫碱配体构筑的双核镧系配合物的合成、晶体结构及与DNA相互作用 | |
| Synthesis, crystal structure, and DNA-binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand | |
| 摘要: 合成了具有良好生物活性的多齿席夫碱H3L (羟基乙酸(4-二乙胺-2-羟基苄基)-肼)，并以其为配体合成了2例双核镧系配合物[Ln2(dbm)2(HL)2(CH3OH)2]·4CH3OH，其中Hdbm=二苯甲酰甲烷，Ln=Tb (1)、Dy (2)。结构表征显示该类配合物由2个稀土金属离子与2个dbm-配体，2个HL2-配体，2个配位的CH3OH分子以及4个游离的CH3OH分子组成。每个中心Ln (Ⅲ)为八配位。2个Ln (Ⅲ)与2个μ2-O原子(O2和O2a)构成了一个近似菱形的[Ln2O2]结构。采用紫外可见光谱法、荧光滴定法和循环伏安法研究了配体H3L以及配合物1和2与小牛胸腺DNA (CT-DNA)相互作用机理。结果表明，配合物1和2均能与CT-DNA分子发生插入作用。 | |
| 关键词: 双核镧系配合物 晶体结构 多齿席夫碱 DNA 插入作用 | |
| 基金项目: 山西省应用基础研究基金(No.202303021212256)资助。 | |
| Abstract: Two new dinuclear lanthanide(Ⅲ) complexes, namely [Ln2(dbm)2(HL)2(CH3OH)2]·4CH3OH [Ln=Tb (1) and Dy (2), Hdbm=dibenzoylmethane] have been synthesized using prepared multidentate Schiff base ligand H3L (hydroxy-acetic acid(4-diethylamino-2-hydroxy-benzylidene)-hydrazide) with good biological activity. Structure characterizations show that the complex comprises two Ln3+ ions, two dbm- ions, two HL2- ligands, two CH3OH molecules, and four free methanol molecules. Each Ln3+ ion is eight-coordinated. The two central Ln(Ⅲ) ions are bridged by two μ2-O atoms leading to a parallelogram [Ln2O2] core. The interaction between the compounds (H3L, 1, and 2) and the calf thymus DNA (CT-DNA) has been further confirmed by UV-Vis spectrometry, fluorescence titration, and cyclic voltammetry. The results showed that both 1 and 2 could undergo insertion with CT-DNA. | |
| Keywords: binuclear lanthanide complexes crystal structures multidentate Schiff base DNA insertion | |
| 投稿时间：2024-04-09 修订日期：2024-09-23 | |
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| 关晓芬,刘娅婷,李佳,胡译文,丁海园,史原晶,王志强,王文敏.基于多齿席夫碱配体构筑的双核镧系配合物的合成、晶体结构及与DNA相互作用[J].无机化学学报,2024,40(12):2486-2496. | |
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| Support information: 相关附件： 20240122_Revised_Supporting_information-20240122.docx | |
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