| 多功能纳米酶普鲁士蓝修饰过氧化铜的合成及其自供过氧化氢的光热增强催化治疗 | |
| Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide | |
| 摘要: 通过在普鲁士蓝(PB)中引入CuO2，得到具有H2O2自供的光热增强类酶活性的多功能纳米材料CuO2/PB。其在模拟肿瘤微环境(TME)中能够产生H2O2，消耗谷胱甘肽(GSH)，并在近红外光照射下进一步增强羟基自由基(·OH)的生成与GSH的消耗。此外，小鼠实验证明CuO2/PB能够用于T2-磁共振成像引导下的肿瘤治疗，在14 d的治疗周期内，结合近红外光照射对肿瘤有明显的抑制作用，实现了光热治疗协同H2O2自供的催化治疗。 | |
| 关键词: 纳米颗粒 普鲁士蓝 催化治疗 光热性能 | |
| 基金项目: 湖北省重点实验室开放基金(No.201911061342001)资助。 | |
| Abstract: A multifunctional nanomaterial CuO2/PB with H2O2 self-supply and photothermal-enhanced enzyme-like activity was obtained by introducing CuO2 into Prussian blue (PB). The simulated tumor microenvironment (TME) can produce H2O2 and consume glutathione (GSH), further enhancing the generation of ·OH and the consumption of GSH with near-infrared light irradiation. In addition, mouse experiments have shown that CuO2/PB can be used for T2 -magnetic resonance imagingguided tumor therapy. In the 14 d treatment cycle, combined with near-infrared light irradiation, it had a significant inhibitory effect on tumors, achieving photothermal therapy combined with H2O2 self-supply catalytic therapy, which provides a new idea for improving the efficiency of catalytic treatment. | |
| Keywords: nanoparticle Prussian blue catalytic therapy photothermal performance | |
| 投稿时间：2024-05-25 修订日期：2024-10-20 | |
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| 王卓亚,贺乐,林志权,王应席,李玲.多功能纳米酶普鲁士蓝修饰过氧化铜的合成及其自供过氧化氢的光热增强催化治疗[J].无机化学学报,2024,40(12):2445-2454. | |
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