| 无机金属配合物光热材料及其光热治疗应用研究进展 |
| Recent developments of inorganic metal complex-based photothermal materials and their applications in photothermal therapy |
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| 摘要: 无机金属配合物的光热材料由于其结构易修饰、性质可调控以及具有高光热转化效率和良好的生物相容性等优势备受关注，近年来在光热诊疗剂领域取得了令人瞩目的成就。本综述以配合物的不同有机配体如卟啉、酞菁、多酚、双(二硫烯)以及氮杂吡咯烷等进行分类，并探讨了其与不同中心金属离子配位后在光热效应及治疗等方面上的效果。基于此，我们综述了近10年研究人员在无机金属配合物光热材料开发及其利用等方面的研究进展，并展望了无机金属配合物光热材料未来可能发展方向，以期进一步促进光热材料的发展及应用。 |
| 关键词: 无机金属配合物 光热材料 配体 光热转化效率 肿瘤靶向 |
| 基金项目: 国家自然科学基金(No.22371124，22377057，21971115)和江苏省自然科学基金(No.BK20221333，BK20211013)资助。 |
| Abstract: Inorganic metal complex-based photothermal materials have garnered significant attention due to their advantages, such as ease of structural modification, tunable properties, high photothermal conversion efficiency, and good biocompatibility. In recent years, remarkable progress has been made in the development of photothermal agents for diagnostics and therapy. This review categorizes these complexes according to different organic ligands, including porphyrin, phthalocyanine, polyphenol, bis(disulfide), and azapyrrolidine, and examines how the coordination of various metal centers, ligand modifications, complex assembly, water solubility regulation, and targeting affect the photothermal properties and therapeutic performance. Additionally, we summarize the research advancements of the past decade in inorganic metal complex photothermal materials and offer insights into potential future directions to further advance their development and application. |
| Keywords: inorganic metal complex photothermal material ligand photothermal conversion efficiency tumor targeting |
| 投稿时间：2024-07-04 修订日期：2024-09-08 |
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| 张文静,王小青,刘志鹏.无机金属配合物光热材料及其光热治疗应用研究进展[J].无机化学学报,2024,40(12):2356-2372. |
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