| 原子精确币金属纳米团簇在肿瘤治疗中的研究进展 |
| Research advances of atomic precision coinage metal nanoclusters in tumor therapy |
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| 摘要: 恶性肿瘤是对人类健康严重的威胁之一，而建立高效、精准的肿瘤治疗技术一直都是被广泛研究的热点。随着纳米医学技术的快速发展，纳米材料介导的肿瘤治疗技术因其内侵袭性小、特异性高、治疗效果好等优点被科学研究人员所关注。作为纳米材料家族中的新成员，原子精确的币金属纳米团簇由于其良好的生物相容性、表面可修饰性、良好的光学特性和高效的催化活性(产生活性氧)等特点，在肿瘤治疗方面展现出潜在的应用前景。本篇综述主要讨论了原子精确币金属纳米团簇在肿瘤治疗中的研究进展，根据不同的治疗方法(放射疗法、光热疗法、光动力疗法、化学动力学疗法、药物递送及多模态联合治疗)，详细介绍了币金属纳米团簇在肿瘤治疗中的作用机制。此外，对当前金属纳米团簇在肿瘤治疗中所面临的挑战进行了总结，并对其未来的发展进行了展望。 |
| 关键词: 原子精确 币金属纳米团簇 肿瘤 治疗 |
| 基金项目: 国家自然科学基金(No.22171007)、安徽省自然科学基金(No.2308085Y08)和安徽医科大学科研启动基金(No.XJ2020026)资助。 |
| Abstract: Malignant tumors are one of the most serious threats to human health, and it has been a wildly discussed topic to establish efficient and accurate tumor treatment techniques. With the rapid development of nanomedicine technology, nanomaterial-mediated tumor treatment techniques have attracted more attention due to their low invasiveness, high specificity, and good therapeutic effects. As a new member of the nanomaterial family, atomically precise coinage metal nanoclusters show great potential in tumor treatment due to their excellent biocompatibility, surface modifiability, good optical properties, and efficient catalytic activity (generation of reactive oxygen species). This review mainly discusses the progress of research on atomically precise coinage metal nanoclusters in tumor treatment. Their antitumor mechanism is detailed in different therapies (radiation therapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, drug delivery, and multimodal combination therapy). Moreover, the current challenges and prospects of metal nanoclusters in antitumors are summarized. |
| Keywords: atomically precise coinage metal nanocluster tumor therapy |
| 投稿时间：2024-06-20 修订日期：2024-10-24 |
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| 许婷婷,张文静,宋永波.原子精确币金属纳米团簇在肿瘤治疗中的研究进展[J].无机化学学报,2024,40(12):2275-2285. |
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