| 氮、硫共掺杂碳点对黄芩素的高灵敏检测及在生物流体中的应用 | |
| High sensitivity detection of baicalein by N, S co-doped carbon dots and their application in biofluids | |
| 摘要: 以对苯二胺和L-半胱氨酸为原料，通过一步溶剂热法制备了性能优异的水溶性氮、硫共掺杂碳点(N，S-CDs)。利用透射电子显微镜、X射线衍射、傅里叶变换红外光谱和X射线光电子能谱对N，S-CDs的形貌和结构进行了表征，并利用紫外可见吸收光谱和荧光光谱对其基本光物理性质进行了研究。同时，N，S-CDs在pH、离子强度、辐射时间和储存时间方面表现出优异的发光稳定性。实验结果表明，该传感器平台对黄芩素表现出高灵敏、高选择性响应，检出限为85 nmol·L-1，其猝灭机理为内滤效应。此外，该传感器还可以在生物流体(血清和尿液)中检测黄芩素，表现出良好的准确性和重现性。 | |
| 关键词: 氮、硫掺杂碳点 溶剂热法 黄芩素 荧光传感器 | |
| 基金项目: 国家自然科学基金(No.22302144)、山西省基础研究计划青年项目(No.20210302124217，202103021223332)、大学生创新创业训练项目(No.CXCY2435)和蛋白质基功能材料实验室(No.2022P010)资助。 | |
| Abstract: In this work, p-phenylenediamine and L-cysteine were used as raw materials, and water-soluble N, S co-doped carbon dots (N, S-CDs) with excellent performance were prepared through a one-step solvothermal method. The morphology and structure of N, S-CDs were characterized by transmission electron microscope, X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy, and the basic photophysical properties were investigated via UV-Vis absorption spectra and fluorescence spectra. Meanwhile, the N, S-CDs have excellent luminescence stability with pH, ionic strength, radiation time, and storage time. Experimental results illustrated the present sensor platform exhibited high sensitivity and selectivity in response to baicalein with a detection limit of 85 nmol·L-1. The quenching mechanism is proved to be the inner filter effect. In addition, this sensor can also detect baicalein in biofluids (serum and urine) with good accuracy and reproducibility. | |
| Keywords: N, S-carbon dots solvothermal method baicalein fluorescent sensor | |
| 投稿时间：2024-04-08 修订日期：2024-07-17 | |
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| 范俊梅,刘玮,朱瑞涛,秦晨曦,雷晓灵,王浩田,王姣,韩红斐.氮、硫共掺杂碳点对黄芩素的高灵敏检测及在生物流体中的应用[J].无机化学学报,2024,40(10):2009-2020. | |
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