| 两个含5-苯基-1H-吡唑锌(Ⅱ)配合物的合成、晶体结构及抗菌活性 |
| Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group |
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| 摘要: 在甲醇中用氨基硫脲和苯甲酰丙酮反应，合成了一种新颖的化合物(H2L)SCN(5-methyl-3-phenyl-2H-pyrazol-1-ium thiocya-nate)。在回流条件下，二水醋酸锌或氯化锌与(H2L)SCN 发生配位反应，合成了 2 种锌(Ⅱ)配合物[Zn(HL)2(NCS)(CH3COO)] (1)和[Zn2(L)2(HL)2(NCS)2]2·2CH3OH (2)。合成的化合物的结构均通过元素分析和单晶X射线衍射确认。配体(H2L)SCN和配合物1属于三斜晶系P1空间群，配合物2属于单斜晶系P21/n空间群。此外，采用琼脂扩散法评价了化合物对白色念珠菌、金黄色葡萄球菌和大肠杆菌菌株的体外抗菌活性。结果表明，配体对这些细菌具有较好的抗菌活性，配合物对同一细菌的抗菌活性比配体更强。 |
| 关键词: 锌(Ⅱ)配合物 5-苯基-1H-吡唑 硫氰酸根 晶体结构 细菌 |
| 基金项目: 安徽省高校自然科学重点研究项目(No.KJ2020A0737)和国家级大学生创新创业训练计划项目(No.202310379009)资助。 |
| Abstract: A novel compound (H2L) SCN (5-methyl-3-phenyl-2H-pyrazol-1-ium thiocyanate) has been obtained by the reaction of thiosemicarbazide with benzoylacetone in ethanol. Two zinc(Ⅱ) complexes [Zn(HL)2(NCS)(CH3COO)] (1) and [Zn2(L)2(HL)2(NCS)2]2·2CH3OH (2) have been synthesized by the coordination reactions of Zn(OAc)2·2H2O or ZnCl2 with (H2L) SCN under reflux conditions. Elemental analyses and singlecrystal X-ray diffraction have confirmed the structures of the synthesized compounds. The (H2L) SCN ligand and complex 1 pertain to the triclinic system with space group P1, while complex 2 belongs to the monoclinic system with space group P21/n. Additionally, the antibacterial activities of the compounds were evaluated in vitro using the agar diffusion method against the bacterial strains (Candida albicans, Staphylococcus aureus, and Escherichia coli). The results showed that the ligand exhibited relatively good antibacterial activities against the bacteria, and the complexes possessed stronger antibac-terial activities against the same bacteria than the free ligand. |
| Keywords: zinc(Ⅱ) complex 5-phenyl-1H-pyrazole thiocyanate crystal structure bacteria |
| 投稿时间：2024-05-04 修订日期：2024-08-28 |
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| 刘超,吴疆,金赵磊.两个含5-苯基-1H-吡唑锌(Ⅱ)配合物的合成、晶体结构及抗菌活性[J].无机化学学报,2024,40(10):1986-1994. |
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| Support information: 相关附件： 20240153_Supplementary_materials(修改后).doc |
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