| 两例LnⅢ3配合物的构筑、晶体结构及生物活性 | |
| Construction, crystal structures, and biological activities of two LnⅢ3 complexes | |
| 摘要: 利用多齿席夫碱配体H2L(H2L=(E)-6-(羟甲基)-N'-((6-甲氧基吡啶-2-基)亚甲基)吡啶酰肼)与Ln(dbm)3·2H2O反应，通过溶剂热法，设计与构筑了 2例新的三核稀土配合物[Ln3(dbm)5(L)2(CH3OH)2]·CH2Cl2，其中 Ln=Pr (1)、Ho (2)，Hdbm=二苯甲酰甲烷。单晶 X射线衍射分析表明：配合物 1与 2同构，其结构由 3个 Ln(Ⅲ)离子、5个二苯甲酰甲烷阴离子(dbm-)、2个席夫碱配体 L2-、2个配位的 CH3OH及 1个结晶 CH2Cl2分子组成。3个中心 Ln(Ⅲ)离子通过 4个 μ2-O原子相互连接，形成折线形的 Ln3核。生物活性研究表明，配体H2L、Ln(dbm)3·2H2O及配合物1和2均具有较好的抑菌活性。与配体H2L及Ln(dbm)3·2H2O相比较，稀土配合物具有更强的抑菌活性。此外，采用紫外光谱法、循环伏安法和荧光光谱法研究了配合物1和2与小牛胸腺DNA(ctDNA)之间的相互作用，结果表明配合物主要以插入键合的方式与ctDNA结合。 | |
| 关键词: 稀土配合物 席夫碱配体 晶体结构 生物活性 DNA作用 | |
| 基金项目: 山西省高校科技创新项目(No.2021L404)资助。 | |
| Abstract: Two new trinuclear Ln -based complexes with the formula [Ln3(dbm)5(L)2(CH3OH)2]·CH2Cl2 (Ln=Pr (1), Ho (2); Hdbm=dibenzoylmethane) have been constructed via the solvothermal method by using a polydentate Schiff base ligand H2L (H2L=(E)-6-(hydroxymethyl)-N'-((6-methoxypyridin-2yl)methylene)picolinohydrazide) reacting with Ln(dbm)3·2H2O. Single crystal X ray diffraction reveals that complexes 1 and 2 are isostructural, and their structures are mainly composed of three Ln(Ⅲ) ions, five dbm- ions, two L2- ions, two coordinated CH3OH molecules, and one lattice CH2Cl2 molecule. The three central Ln(Ⅲ) ions are connected by four μ2-O atoms forming a folded Ln3 core. Notably, complexes 1 and 2 show promising antibacterial activity and exhibit stronger bacteriostatic activities compared to their precursor components. Additionally, their interaction with calf thymus DNA (ctDNA) was studied using ultraviolet spectroscopy, cyclic voltammetry, and fluorescence spectroscopy, demonstrating their ability to bind to ctDNA mainly by intercalation. | |
| Keywords: lanthanide complexes Schiff base ligand crystal structures biological activities DNA-binding | |
| 投稿时间：2024-05-21 修订日期：2024-06-19 | |
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| 王海堂,凌妍妮,马夏清,陈雨鑫,张瑞,王可怡,张莹,王文敏.两例LnⅢ3配合物的构筑、晶体结构及生物活性[J].无机化学学报,2024,40(8):1474-1482. | |
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| Support information: 相关附件： 20240188_Revised_Supporting_Information-20240188 (1).docx | |
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