| 基于席夫碱配体构筑的LnⅢ2配合物的结构、荧光性质及生物活性 | |
| Crystal structure, fluorescence properties, and biological activity of LnⅢ2 complexes based on Schiff base ligand | |
| 摘要: 以多齿席夫碱配体H2L (H2L=(E)-N'-(3-乙氧基-2-羟基亚苄基)-3-羟基吡啶甲酰肼)为配体，与Ln (acac)3·2H2O (Ln=Tb、Ho、Er； acac-=乙酰丙酮根)反应，通过溶剂热法，成功得到了3例新的双核稀土配合物[Ln2(acac)2(L)2(C2H5OH)2](Ln=Tb (1)、Ho (2)、Er (3))。单晶X射线衍射分析表明：配合物1~3的结构主要由2个LnⅢ离子、2个乙酰丙酮根(acac-)、2个L2-及2个C2H5OH组成，中心LnⅢ离子通过2个μ2-O原子相互连接，形成一个平行四边形的Ln2O2核心。固体荧光实验测试结果表明：配合物1在室温下表现出TbⅢ离子的荧光特征发射峰。此外，生物活性研究表明，与配体H2L和稀土离子相比较，配合物1~3具有更强的抗菌活性。采用紫外光谱法、循环伏安法、凝胶电泳法和荧光光谱法研究了配合物1~3与小牛胸腺DNA之间的相互作用，结果表明配合物主要以插入作用的方式与小牛胸腺DNA结合。 | |
| 关键词: Ln2配合物 晶体结构 荧光性质 生物活性 DNA作用 | |
| 基金项目: 山西省高校科技创新项目(No.2021L404)资助。 | |
| Abstract: Three new binuclear Ln-based complexes with the formula [Ln2(acac)2(L)2(C2H5OH)2] (Ln=Tb (1), Ho (2), Er (3); acac-=acetylacetonate) have been synthesized via the solvothermal method by using a polydentate Schiff base ligand (H2L=(E)-N'-(3-ethoxy-2-hydroxyb enzylidene)-3-hydroxypicolinohydrazide) reacting with Ln(acac)3·2H2O. Single-crystal X-ray structures reveal that complexes 1-3 are mainly composed of two LnⅢ ions, two acac- ions, two L2- ions, two C2H5OH molecules, and the two central LnⅢ ions are connected by two μ2-O atoms forming a“parallelogram-shaped”Ln2O2 core. The solid-state fluorescence property shows that the emission spectrum of complex 1 exhibited the characteristic emissions of TbⅢ ions under the excitation of 296 nm. For complex 1, four characteristic emission peaks were observed at 490, 545, 585, and 620 nm, corresponding to the transitions of TbⅢ ion from 5D4 to 7F J (J=6, 5, 4, 3). In addition, the biological activity study shows that complexes 1-3 had stronger antibacterial activity than H2L and Ln(acac)3·2H2O. The interaction between complexes 1-3 and DNA was studied by ultraviolet spectroscopy, cyclic voltammetry, gel electrophoresis, and fluorescence spectroscopy. The results reveal that complexes 1-3 could bind to calf thymus DNA mainly by intercalation. | |
| Keywords: Ln2 complexes crystal structures fluorescence properties biological activity DNA-binding | |
| 投稿时间：2022-07-12 修订日期：2022-11-11 | |
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| 辛晓艳,陈凤姣,李文钰,王捷,杨晨,李敏,石瑛,王文敏.基于席夫碱配体构筑的LnⅢ2配合物的结构、荧光性质及生物活性[J].无机化学学报,2023,39(1):1-12. | |
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| Support information: 相关附件： 220317_Supporting_information.doc | |
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