| N-O螯合配体协同膦配体的银(Ⅰ)混配配合物的设计、结构和生物活性 | |
| A Complex of Silver(Ⅰ) with N-O Chelating Agent and Phosphine Ligand: Design, Structures, and Biological Activity | |
| 摘要: 合成了一种Ag （Ⅰ）配合物[Ag （Qina）（Tpp）2]·1.5H2O （Qina=2-喹啉羧酸根，Tpp=三苯基膦）。运用单晶X射线衍射、IR、NMR和粉末X射线衍射对配合物的结构进行了表征。配合物属于单斜晶系，C2/c空间群，晶胞参数：a=3.195 90（13） nm，b=1.210 96（4） nm，c=2.319 74（7） nm，β=102.166（4）°，V=8.776 0（5） nm3，Z=8。通过Hirshfeld表面分析，推导出配合物的超分子结构和分子间弱作用力。同时，通过DNA结合活性测试、抗菌活性和癌细胞体外毒活性测试，评价了配合物的生物活性。 | |
| 关键词: 银(Ⅰ)配合物 Hirshfeld表面电荷分析 晶体结构 生物活性 | |
| 基金项目: 贵州省普通高等学校青年科技人才成长项目（黔教合KY字[2020]123）、贵州省煤炭洁净利用重点实验室（黔科合平台人才[2020]2001）资助 | |
| Abstract: A new Ag(Ⅰ) complex,[Ag(Qina) (Tpp)2]·1.5H2O (Qina=2-quinolinecarboxylate, Tpp=triphenylphosphine), was synthesized and successfully obtained as a single crystal. The structure of the complex was characterized by single-crystal X-ray diffraction, IR, NMR, and powder X-ray diffraction. The results show that the complex belongs to monoclinic crystal system, C2/c space group, and the unit cell parameters are a=3.195 90(13) nm, b=1.210 96(4) nm, c=2.319 74(7) nm, β=102.166(4)°, V=8.776 0(5) nm3, and Z=8. The supramolecular structures and weak intermolecular force of the complex were deduced by Hirshfeld surface analysis. Meanwhile, the biological activities of the complex were tested by evaluating DNA-binding efficacy, antibacterial activity, and in vitro toxic activity of cancer cells. | |
| Keywords: Ag(Ⅰ) complex Hirshfeld surface analysis crystal structures biological activity | |
| 投稿时间：2022-01-24 修订日期：2022-05-10 | |
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| 王仁舒,冯静,王远兰,欧阳晨枫.N-O螯合配体协同膦配体的银(Ⅰ)混配配合物的设计、结构和生物活性[J].无机化学学报,2022,38(8):1609-1622. | |
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| Support information: 相关附件： 220035-Supporting_information.docx | |
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