| 各种二茂铁基席夫碱的合成、表征和对革兰氏阳性和革兰氏阴性细菌的抗菌筛选 |
| Synthesis, Characterization and Antimicrobial Screening of Various Ferrocenyl Schiff Bases against Gram-positive and Gram-negative Bacteria |
| 作者 | 单位 | E-mail | | Oladeji S. Olatunde | Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa | | | Ikhile I. Monisola | Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa | miikhile@gmail.com | | Mamo Messai | Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa | | | Ndungu G. Patrick | Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa | | | Ndinteh T. Derek | Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa | dndinteh@uj.ac.za，Cell：+234 80 62312429 |
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| 摘要: 合成了10种二茂铁基席夫碱1~10，并采用UV-Vis光谱、FT-IR、元素分析、1H和13C NMR谱对其进行了表征。评价了所合成的化合物对11种细菌菌株(枯草芽孢杆菌ATCC19659、产气克雷伯氏菌肠杆菌ATCC13882、粪肠球菌ATCC13047、耻垢分枝杆菌MC2155、表皮葡萄球菌ATCC14990、金黄色葡萄球菌ATCC25923、大肠杆菌ATCC25922、阴沟肠杆菌ATCC13047、产酸克雷伯氏菌ATCC8724、奇异变形杆菌ATCC7002、普通变形杆菌ATCC6380)的抗菌活性。抗菌试验结果表明，与标准物萘啶酸和硫酸链霉素对比，合成的席夫碱1~10可抑制产气克雷伯氏菌和粪肠球菌的潜在生长，最低抑菌浓度(MIC)分别为15.6~31.25和31.25~125μg·mL-1。 |
| 关键词: 抗菌 席夫碱 萘啶 合成 抑制 |
| 基金项目: |
| Abstract: Ten ferrocenyl Schiff bases 1-10 were synthesized and characterized using UV-Vis spectroscopy, FT-IR, elemental analysis, 1H and 13C NMR spectroscopy. The synthesized compounds were evaluated against 11 bacteria strains (Bacillus subtilis ATCC19659, Klebsiella aerogenes ATCC13882, Enterococcus faecalis ATCC13047, Mycobacterium smegmatis MC2155, Staphylococcus epidermidis ATCC14990, Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922, Enterobacter cloacae ATCC13047, Klebsiella oxytoca ATCC8724, Proteus mirabilis ATCC7002, Proteus vulgaris ATCC6380). The results obtained from antibacterial assay indicated that the synthesized Schiff bases 1-10 inhibited potential growth of Klebsiella aerogenes with the minimum inhibitory concentration (MIC) ranging from 15.6 to 31.25 μg·mL-1 and Enterococcus faecalis with MIC the range between 31.25 and 125 μg· mL-1 in comparison with the standard nalidixic acid and streptomycin sulfate. |
| Keywords: antibacterial Schiff bases nalidixic synthesis inhibition |
| 投稿时间：2021-05-10 修订日期：2021-11-24 |
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| Oladeji S. Olatunde,Ikhile I. Monisola,Mamo Messai,Ndungu G. Patrick,Ndinteh T. Derek.各种二茂铁基席夫碱的合成、表征和对革兰氏阳性和革兰氏阴性细菌的抗菌筛选[J].无机化学学报,2022,38(4):705-715. |
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| Support information: 相关附件： file210213-Supplementary data.docx |
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