| 香豆素衍生物荧光传感器对Zn2+的识别及细胞成像 |
| Recognition and Cell Imaging of Zn2+ by Coumarin Derivative Fluorescence Sensor |
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| 摘要: 制备了基于香豆素衍生物的荧光传感器CANQ，其可选择性地识别Zn2+离子。通过NMR、MS、荧光光谱等技术研究了传感器的结构及荧光性能。传感器CANQ对Zn2+离子具有显著的荧光增强响应，且响应速度快、选择性高、生物相容性好，可用于MCF-7细胞中Zn2+离子的成像。 |
| 关键词: Zn2+离子 香豆素衍生物 荧光传感器 识别 |
| 基金项目: 大连市高层次人才创新支持计划（No.2019RQ039）和中央高校基本科研业务费专项资金（No.DUT20LK12）资助 |
| Abstract: Coumarin-derived fluorescence sensor was designed and synthesized to selectively recognize Zn2+ ions. The structure and fluorescence properties of the sensor were investigated by NMR, MS, fluorescence spectroscopy, and other technical methods. Sensor CANQ exhibited conspicuous fluorescent enhancement response to Zn2+ ion and had the characteristic of fast response, high selectivity, and good biocompatibility. It has been applied to the imaging of Zn2+ ions in MCF-7 cells. |
| Keywords: Zn2+ ion coumarin derivative fluorescent sensor recognition |
| 投稿时间：2021-07-30 修订日期：2021-11-17 |
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| 尹计秋,安永林,贾献超,焦扬.香豆素衍生物荧光传感器对Zn2+的识别及细胞成像[J].无机化学学报,2022,38(2):368-376. |
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