| 用于生物成像的三线态-三线态湮灭上转换发光纳米胶囊 |
| Triple-Triplet Annihilation Upconversion Nanocapsules for in Vivo Bioimaging |
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| 摘要: 为解决三线态-三线态湮灭上转换发光材料（TTA-UC）生物应用时固载化困难的问题，通过一步细乳液聚合法合成了以正十六烷为内核，以红光激发的硅酞菁为敏化剂和发光高效的红荧烯为受体，具有优异上转换发光性能的核壳结构纳米胶囊（TTA-UCNP）。TTA-UCNP粒径约为190 nm，均一性及分散性良好。体系引入了抗氧化剂D-柠檬烯和聚异丁烯，有效消除了氧气分子对上转换发光过程的淬灭，保证了上转换发光的稳定性。在动物成像应用中，TTA-UCNP成功实现了活体层次前哨淋巴结高信噪比的成像及长时间示踪。 |
| 关键词: 上转换发光 生物成像 三线态-三线态湮灭 细乳液聚合法 |
| 基金项目: 国家重点基础研究发展计划（No.2017YFA0205100）资助项目 |
| Abstract: To solve the problem that it is difficult to immobilize triple-triplet annihilation based upconversion (TTAUC) for biological application, water soluble nanocapsules with n-hexadecane core containing a TTA-UC system were synthesized by a one-step miniemulsion polymerization. In the TTA-UC system, silicon phthalocyanine excited by red light source as sensitizer and rubrene with high efficiency as receptor were introduced into n-hexadecane to endow the nanocapsules with upconversion emission. The TTA-UC nanocapsules (TT-UCNP) have a typical coreshell structure with a uniform size of 190 nm. To eliminate the quenching effect of molecular oxygen on upconversion luminescence, D-limonene and polyisobutylene were selected as anti-oxidant, and the TTA-UCNP showed bright upconversion emission. The TTA-UCNP have been successfully applied in in vivo imaging of sentinel lymph node (SLN) with high signal-to-noise ratio and long-term tracing. |
| Keywords: upconverted luminescence bioimaging triple-triplet annihilation miniemulsion polymerization |
| 投稿时间：2020-05-23 修订日期：2020-05-31 |
| 摘要点击次数: 2003 |
| 全文下载次数: 1222 |
| 李振华,袁薇,李富友.用于生物成像的三线态-三线态湮灭上转换发光纳米胶囊[J].无机化学学报,2020,36(10):1934-1940. |
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