| 含硅二烃基锡（Ⅳ）水杨醛缩氨基硫脲席夫碱配合物的合成、结构及抗癌活性 |
| Synthesis, Structure and Antitumour Activity of Diorganotin(Ⅳ) Complexes Containing Silicon of Salicylaldehyde Thiosemicarbazone |
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| 摘要: 合成了11个含硅二烃基锡的水杨醛缩氨基硫脲席夫碱配合物R（Me3SiCH2）SnL（R=Me3SiCH2或Ph，Cy；H2L=水杨醛缩氨基硫脲席夫碱），并通过1H NMR、13C NMR、IR、元素分析和X射线单晶衍射对目标化合物结构进行了表征。结果表明，水杨醛缩氨基硫脲席夫碱作为三齿双阴离子配体，通过酚氧、亚胺氮和硫醇硫与锡（Ⅳ）配位，形成了中心锡原子为五配位的五元杂环与六元杂环的并联结构。生物活性试验的初步结果显示，该类化合物对人体乳腺癌细胞MDA-MB-231和MCF-7具有较好的体外抗癌活性。 |
| 关键词: 二烃基锡 缩氨基硫脲 席夫碱 合成 结构 生物活性 |
| 基金项目: |
| Abstract: Eleven diorganotins containing silicon of salicylaldehyde thiosemicarbazone were synthesized and characterized through 1H NMR, 13C NMR, IR spectra, elemental analysis and X-ray single crystal diffraction tests. The result shows that the thiosemicarbazone Schiff base coordinates with tin atom as tridentate dianionic ligand through thephenolic oxygen, imine nitrogen and mercaptan sulfur, forming a parallel five and six-member heterocyclic structures. The preliminary bioassay result shows that these compounds have a good antitumor activity in vitro against MDA-MB-231 and MCF-7. |
| Keywords: diorganotin thiosemicarbazone Schiff base synthesis structure biological activity |
| 投稿时间：2019-10-17 修订日期：2019-12-27 |
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| 谢波,姚华,廖启华,邓瑞红,林森,严兆华.含硅二烃基锡（Ⅳ）水杨醛缩氨基硫脲席夫碱配合物的合成、结构及抗癌活性[J].无机化学学报,2020,36(5):819-826. |
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