| Meso-四（对甲基苯基）卟啉及其钴配合物的光学性能与生物应用 | |
| Optical Properties and Biological Applications of Meso-tetrakis (p-methylphenyl) Porphyrin and Its Cobalt Complex | |
| 摘要: 对meso-四（对甲基苯基）卟啉（TMPP）和meso-四（对甲基苯基）卟啉钴（TMPP-Co）的溶剂化效应及其水相体系下的发光机理进行了细致地研究。发现TMPP在与钴离子配位后发光强度明显下降；TMPP-Co的溶剂化效应不仅与溶剂极性有关，还与Co离子的轴向配位有关；TMPP与TMPP-Co在水相条件下及在甘油中的发光强度呈现先上升后下降的趋势。此外，TMPP-Co产生单线态氧的能力较强；通过制备TMPP-TAT-NPs纳米粒子成功实现对细胞的染色，并局域在细胞溶酶体上。 | |
| 关键词: TMPP 溶剂化效应 单线态氧 细胞染色 | |
| 基金项目: 国家自然科学基金（No.51673118）和深圳市基础研究计划项目（No.JCYJ20160428150429072）资助。 | |
| Abstract: The solvation effects of meso-tetrakis(p-methylphenyl) porphyrin (TMPP) and meso-tetrakis(p-methylphenyl) porphyrin cobalt (TMPP-Co), and the luminescence mechanism in aqueous systems have been studied in detail. It was found that the luminescence intensity of TMPP after the complexation of cobalt ions decreased significantly; the solvation effect of TMPP-Co was not only related to the polarity of the solvent but also related to the axial coordination of Co ions. The luminous intensities of TMPP and TMPP-Co showed a trend of increase and then decrease both in aqueous phase and in glycerol. In addition, TMPP-Co has a strong ability to generate singlet oxygen; the preparation of TMPP-TAT-NPs nanoparticles successfully stained cells and localized to the cell lysosomes. | |
| Keywords: TMPP photoelectric properties singlet oxygen cell staining | |
| 投稿时间：2018-05-22 修订日期：2018-10-02 | |
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| 张万宇,张晓娟,佟佳霖,陈天赐,田俊强,胡蓉,王志明.Meso-四（对甲基苯基）卟啉及其钴配合物的光学性能与生物应用[J].无机化学学报,2018,34(12):2161-2171. | |
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