| pH药物控释的氮掺杂碳点载运阿霉素用于光热与化疗的协同治疗 |
| pH-Controlled Drug Release of Nitrogen Doped Carbon Dots Delivering Doxorubicine for Synergetic Photo-Thermal Therapy and Chemotherapy |
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| 摘要: 提出一种利用氮掺杂碳点（N-CDs）的光热性能与化疗药物阿霉素（Dox）相结合的联合治疗肿瘤模式。实验结果标明，所制备的N-CDs的分散液经光照后升温可达10℃，是性能优异的光热剂。同时，载运Dox后的N-CDs-Dox纳米复合物还具有pH触发的药物控释作用。因此，这种多功能的N-CDs-Dox纳米复合物能够实现光热和化疗的协同作用，有效杀伤肿瘤细胞。 |
| 关键词: pH药物控释 抗肿瘤剂 氮掺杂碳点 药物载运 水热合成 光热治疗 化疗 协同作用 |
| 基金项目: 国家自然科学基金（No.21571002和No.21671001）和安徽省环境友好高分子材料重点实验室项目。 |
| Abstract: A brand new treatment was reported to cure the cancer triumphantly using the combination of photo-thermal therapy inducing by nitrogen doped carbon dots (N-CDs) and chemotherapy of the doxorubicin (Dox). The experiment results demonstrated that the as-synthesized N-CDs had excellent photo-thermal effect inducing the temperature enhancement as high as about 10℃. Furthermore, the as-prepared N-CDs could load Dox availably and achieve a pH-controlled drug release. Thus, the multifunctional N-CDs-Dox nanocomposites could perform the synergetic effect of photo-thermal therapy and chemotherapy to tumor cells. |
| Keywords: pH-controlled drug release antitumor agents nitrogen doped carbon dots drug deliver hydrothermal synthesis photo-thermal therapy chemotherapy synergistic effect |
| 投稿时间：2018-06-21 修订日期：2018-08-22 |
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| 杨正,谢安建,沈玉华.pH药物控释的氮掺杂碳点载运阿霉素用于光热与化疗的协同治疗[J].无机化学学报,2018,34(10):1775-1782. |
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