| 三明治结构rGO/Fe3O4@mSiO2载体的构筑及协同抗肿瘤性能 |
| Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers |
| 作者 | 单位 | E-mail | | 杨永梅 | 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601
黄山学院化学化工学院, 黄山 245041 | | | 嵇眀翔 | 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601 | | | 杨颖 | 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601 | | | 谢安建 | 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601 | | | 沈玉华 | 安徽大学化学化工学院, 现代生物制造协同创新中心, 合肥 230601 | s_yuhua@163.com |
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| 摘要: 采用温和的反应条件，制备出三明治结构rGO/Fe3O4@mSiO2，利用SEM、TEM、FTIR、XRD和N2吸附-脱附等对其形貌和性能进行表征，考查了其对Hela细胞的毒性和细胞荧光成像效果，并探讨了其形成机理。实验结果表明：rGO/Fe3O4@mSiO2具有较高的比表面积（217 m2·g-1），对抗癌药物五氟尿嘧啶（5-FU）的载药率达到57.34%；它还具有较好的磁性，磁饱和强度为32 emu·g-1；而且rGO/Fe3O4@mSiO2纳米复合物在光照条件下具有优异的光热转换性能，对HeLa细胞表现出明显的杀伤效果。 |
| 关键词: 纳米复合材料 磁靶向 光热治疗 药物载体 协同抗癌 |
| 基金项目: 国家自然科学基金（No.21571002，21671001）和安徽省高校优秀青年骨干人才国内外访学项目（No.gxfx2017105）资助。 |
| Abstract: A novel sandwich-like nanocomposites of rGO/Fe3O4@mSiO2 were successfully fabricated through a facile method. The morphology and properties of nanocomposites were characterized by SEM, TEM, FTIR, XRD and N2 adsorption-desorption. As a result, it was observed that the nanocomposites exhibit the saturation magnetization of 32 emu·g-1, and possess abundant pores with a large surface area as much as 217 m2·g-1. The loading capacity of Pentafluorouracil (5-FU) with the nanocomposites was high(57.34%). The formation mechanism of rGO/Fe3O4@mSiO2 was discussed. Additionally, the synergistic anticancer efficacy of as-prepared nanocomposites against HeLa cell line was investigated by MTT assay and cell fluorescence microscopic imaging analysis. The results indicated that 5-FU loaded in the nanocoposites is effectively delivered to tumor lesion sites under the action of magnetic targeting. Moreover, the rGO/Fe3O4@mSiO2 nanocomposites have excellent photothermal conversion properties under light conditions, and show significant killing effect on HeLa cells. |
| Keywords: nanocomposite magnetic targeting photo-thermal therapy drug carrier synergistic anti-cancer |
| 投稿时间：2018-03-16 修订日期：2018-04-17 |
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| 杨永梅,嵇眀翔,杨颖,谢安建,沈玉华.三明治结构rGO/Fe3O4@mSiO2载体的构筑及协同抗肿瘤性能[J].无机化学学报,2018,34(6):1095-1102. |
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