具有抑菌活性的氮杂环铅配合物的合成、结构及构效关系 |
Syntheses, Structures and Antibacterial Activity of Lead Complexes with Nitrogen Heterocyclic Ligand |
|
摘要: 采用溶液法,在室温条件下合成了2种结构不同的金属铅配合物[Pb(phen)(NO3)(H2O)]NO3(1),[Pb(phen)2(NO3)]NO3(2)(phen=1,10-菲咯啉),并通过元素分析、红外光谱及X射线单晶结构分析对配合物1和2进行了表征。在配合物1中,中心金属Pb(Ⅱ)为四配位,为扭曲的四面体几何构型;在配合物2中,中心金属Pb(Ⅱ)为六配位,形成扭曲的八面体几何构型。配合物1通过分子间氢键形成1D链状超分子结构,而2通过分子间氢键连接形成3D超分子网络结构。配合物1和2对大肠杆菌和金黄色葡萄球菌具有较强抑制作用,配合物2的抑制作用优于配合物1,而且浓度越大,抑制作用越强。 |
关键词: 铅配合物 1,10-菲咯啉 溶液合成 晶体结构 抑菌活性 |
基金项目: 国家自然科学基金(No.21571091)和辽宁省科学事业公益研究基金(No.20170055)资助项目。 |
Abstract: Two lead complexes,[Pb(phen)(NO3)(H2O)]NO3 (1) and[Pb(phen)2(NO3)]NO3 (2) (phen=1,10-phenanthro-line) were synthesized via a solution synthesis method at room temperature. They were characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. In complex 1, the central metal Pb(Ⅱ) is tetra-coordinated to form a distorted tetrahedral geometry. In complex 2, the central metal Pb(Ⅱ) is hexa-coordinated to form a distorted octahedral geometry. By extensive intermolecular hydrogen bonds, complex 1 is connected into 1D chain supramolecular structure, while complex 2 is assembled into 3D supramolecular network. Complexes 1 and 2 have a strong inhibitory effect on Escherichia coli and Golden staph. The higher the concentration, the stronger the inhibitory effect. And the activity of complex 2 is superior to that of complex 1. |
Keywords: lead complexes 1,10-phenanthroline solution synthesis crystal structure antifungal activity |
投稿时间:2017-09-21 修订日期:2018-01-20 |
摘要点击次数: 1597 |
全文下载次数: 1505 |
白凤英,王学敏,曲长庆,王玉,邢永恒.具有抑菌活性的氮杂环铅配合物的合成、结构及构效关系[J].无机化学学报,2018,34(4):639-646. |
查看全文 查看/发表评论 下载PDF阅读器 |
Support information: 相关附件: file170577_补充材料R1.docx |
|
|
|