| 由4-甲基-1,2,3-噻二唑-5-甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用 |
| Syntheses, Crystal Structures and DNA Binding of Transition Metal Complexes Constructed by 4-Methyl-1,2,3-thiadiazol-5-carboxylic Acid |
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| 摘要: 以4-甲基-1，2，3-噻二唑-5-甲酸（C4H4N2O2S，HL）分别与硫酸钴（CoSO4·7H2O）、氯化铜（CuCl2·2H2O）、硝酸银（AgNO3）反应合成了3个配合物[Co（L）2（H2O）4]·2H2O（1）、[CuNa（L）3]n（2）和[AgL]n（3），用元素分析、红外光谱、热重分析进行表征，用单晶X射线衍射测定了产物的结构。配合物1属于三斜晶系，空间群P1，Co2+的配位数为6，形成一个略为拉长的CoN2O4八面体，与理想的正八面体非常接近。配合物2属于三斜晶系，空间群P1。Cu2+离子的配位数为4，构成变形的平面四边形结构，Na+离子的配位数为6，构成一个略微变形的八面体结构，最终形成三维网状结构。配合物3属于单斜晶系，空间群P21/c，银离子为三配位，构成变形的平面三角形构型，具有二维网状结构。用溴化乙锭荧光探针法测定了配体和配合物与DNA作用的荧光光谱。 |
| 关键词: 2-甲基-1,2,3-噻二唑-5-甲酸 过渡金属配合物 晶体结构 DNA作用 |
| 基金项目: 浙江省公益性技术应用研究计划项目（No.2014C32014）资助。 |
| Abstract: Three transition metal complexes[Co(L)2(H2O)4]·2H2O (1),[CuNa(L)3]n (2) and[AgL]n (3) were synthesized from 4-methyl-1,2,3-thiadiazol-5-carboxylic acid(C4H4N2O2S, HL), CoSO4·7H2O, CuCl2·2H2O, and AgNO3. They were characterized by elemental analysis, infrared spectrum, thermogravimetricanalysis (TGA). The crystal structures of the complexes were confirmed by single X-ray diffraction method. Complex 1 crystallizes in triclinic system with space group P1, Co2+ ion is six-coordinated to constitute a slightly deformation octahedral structure. Complex 2 crystallizes in triclinic system with space group P1. Cu2+ ion is four-coordinated to form a quadrilateral plane structure deformation, and Na+ ion is six-coordinated to constitute a slightly deformation octahedral structure, eventually forming a three-dimensional network structure. Complex 3 crystallizes in monoclinic system with space group P21/c, and its coordination number is three, forming a deformation plane triangle configuration with 2D network structure. In addition, DNA-binding of the ligand and complexes was studied by EtBr fluorescent probe method. |
| Keywords: 4-methyl-1,2,3-thiadiazol-5-carboxylic acid transition metal complex crystal structure DNA-binding |
| 投稿时间：2017-01-20 修订日期：2017-06-28 |
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| 严世承,胡未极,沈金杯,赵国良.由4-甲基-1,2,3-噻二唑-5-甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用[J].无机化学学报,2017,33(8):1381-1389. |
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