| 基于碳纳米管负载的电催化剂高效检测还原型谷胱甘肽 |
| An Electrocatalyst Based on Carbon Nanotubes with a High Sensitivity for Detection of Reduced Glutathione |
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| 摘要: 通过两步法合成了10-甲基吩噻嗪/2-羟丙基-β-环糊精主客体化合物修饰的多壁碳纳米管复合材料MPT-HP-β-CD/MWNT，并用FT-IR、UV-Vis、荧光光谱、拉曼光谱、TEM等对其组成进行表征。通过CV曲线、i-t曲线对谷胱甘肽（GSH）的催化性能以及对催化剂阻抗的研究，证明了MWNT可以提高导电能力，提高对GSH的催化活性。此外，还研究了pH值、温度、扫速等对催化剂催化活性的影响，表明该复合材料可用于GSH的电化学检测，并具有良好的稳定性、重现性以及很高的灵敏度。最优检测浓度范围为5×10-7~4.95×10-5 mol·L-1，检测限为3.96×10-8 mol·L-1（S/N=3）。 |
| 关键词: 谷胱甘肽 2-羟丙基-β-环糊精 10-甲基吩噻嗪 多壁碳纳米管 电化学检测 |
| 基金项目: 国家自然科学基金（No.21465011，51563009）、江西省青年科学基金（No.20151BAB213015）和江西省主要学科学术和技术带头人计划（No.20133BCB22007）资助项目。 |
| Abstract: 10-Methylphenothiazine/2-hydroxypropyl-β-cyclodextrin guest-host compounds were mixed with single-walled carbon nanotubes to give composite materials MPT-HP-β-CD/MWNT by a two-step method, which were characterized by FT-IR, UV-Vis, fluorescence spectroscopy, Raman spectrum and TEM. The applications of these composite materials toward the catalytic oxidation of glutathione (GSH) were demonstrated by cyclic voltammetry measurements. These results proved that the presence of MWNT could improve the electrical conductivity and catalytic activity of the composite material. The influences of the pH value, temperature, and scan rate on the catalyst activity were examined. These studies suggest that the MPT-HP-β-CD/MWNT composite materials could be used for the electrochemical detection of GSH with good stability and reproducibility and high sensitivity. The optimal detection concentration is 5×10-7~4.95×10-5 mol·L-1 and the detection limit is 3.96×10-8 mol·L-1 (S/N=3). |
| Keywords: glutathione 2-hydroxypropyl-β-cyclodextrin 10-methylphenothiazine multi-walled carbon nanotubes electrochemical detection |
| 投稿时间：2016-01-07 修订日期：2016-09-07 |
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| 熊乐艳,张楠,李雪妮,郭赞如,郑龙珍.基于碳纳米管负载的电催化剂高效检测还原型谷胱甘肽[J].无机化学学报,2016,32(11):1942-1950. |
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