| 双模板介导合成类骨磷灰石的研究进展 |
| Research Progress in Bi-template Induced Biomimetic Self-assembly of Bone-like Apatite |
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| 摘要: 天然骨形成是一个多模板协同共组装的过程。与单模板自组装相比，双模板介导合成的类骨磷灰石具有与天然骨更加相近的多级结构，在生物矿化研究领域具有更重要的研究意义。本文介绍了双模板介导合成类骨磷灰石的研究进展，探讨了双模板的选择、设计及模板分子间的相互作用，阐述了模板对磷灰石晶体成核的调控机制。通过双模板介导自组装生成的磷灰石材料，以其特有的仿生多级结构和骨诱导效果，在骨缺损修复、齿科修复、表面涂层及药物载体等领域具有广阔的应用前景。 |
| 关键词: 双模板 生物矿化 类骨磷灰石 共组装 |
| 基金项目: 高等学校博士学科点专项科研基金（No.20110142110034）资助项目。 |
| Abstract: Natural bone is an outcome of a multi-template co-assembly process. Compared to single-template self-assembly, bone-like apatite induced by bi-template exhibits more common features and similarities of natural bone that has attracted a wide attention in field of biomineralization. This paper summarizes the recent research achievements in bi-template-induced biomimetic self-assembled apatite. The design of bi-template molecule and the interactions between the molecular templates have been investigated as well as the regulation mechanism of apatite nucleation. The bi-template co-assembly strategy as a promising clinical application has been applied on many fields ranging from bone/teeth repair, coatings and drug delivery, due to the improved osteoconductive properties and even osteoinductive properties. |
| Keywords: bi-template biomineralization hydroxyapatite co-assembly |
| 投稿时间：2016-06-12 修订日期：2016-09-19 |
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| 杨琴,杜莹莹,王江林,张胜民.双模板介导合成类骨磷灰石的研究进展[J].无机化学学报,2016,32(11):1885-1895. |
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