| 基于一种酰腙和咪唑配体的铜(Ⅱ)、镍(Ⅱ)配合物的水热合成、晶体结构及体外抗癌活性 |
| Syntheses, Crystal Structures and in Vitro Antitumor Activities of Copper(Ⅱ) and Nickel(Ⅱ) Complexes Based on Acylhydrazone and Imidazole Ligands |
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| 摘要: 采用水热法合成了5-硝基水杨醛缩噻吩-2-甲酰腙的铜和镍配合物[Cu（Him）L]2（1）和[Ni（Him）L]（2）（H2L=5-硝基水杨醛缩噻吩-2-甲酰腙，Him=咪唑）并经元素分析、红外光谱和紫外光谱表征。X射线单晶衍射分析表明，1的晶体属单斜晶系，空间群P21/c，晶胞参数：a=1.135 68（12）nm，b=0.770 45（8）nm，c=2.140 4（2）nm，β=97.405（3）°。2的晶体属三斜晶系，空间群P1，晶胞参数：a=0.726 91（4）nm，b=0.976 34（6）nm，c=1.265 74（8）nm，α=79.533（2）°，β=82.862（2）°，γ=68.985（2）°。1是中心对称的双核配合物，Cu（Ⅱ）处于四方锥配位环境；2是单核配合物，Ni（Ⅱ）处于平面四边形的配位环境。化合物1通过N-H…O氢键形成一维超分子链，而化合物2通过N-H…O和C-H…O氢键形成二维超分子网络。初步研究了配体和配合物的体外抗癌活性。结果表明，配合物1和2对人肝癌细胞HEPG2和人结肠癌细胞SW620均有较强的增殖抑制作用。 |
| 关键词: 酰腙 配合物 晶体结构 抗癌活性 |
| 基金项目: 泉州师范学院学科建设资金和福建省大学生创新创业训练计划项目（No.201510399025，201510399030）资助。 |
| Abstract: Two new complexes[Cu(Him)L]2 (1) and [Ni(Him)L] (2), where H2L is 2-thiophenecarboxylic acid (2-hydroxly-5-nitro-benzylidene)-hydrazide and Him is imidazole, were synthesized by hydrothermal reaction and characterized by elemental analysis, FT-IR and electronic spectra. The structure of complexes has been accomplished by single crystal X-ray diffraction which results confirmed that the crystal of 1 belongs to the monoclinic system,space group P21/c with cell parameters:a=1.135 68(12) nm, b=0.770 45(8) nm, c=2.140 4(2) nm, β=97.405(3)° and the crystal of 2 belongs to the triclinic system, space group P1 with cell parameters:a=0.726 91(4) nm, b=0.976 34(6) nm, c=1.265 74(8) nm, α=79.533(2)°, β=82.862(2)°, γ=68.985(2)°. The X-ray analyses revealed that 1 displays a centrosymmetric binuclear structure with the Cu atoms in square pyramidal coordination. The binuclear units are further linked by hydrogen bonds to generate an infinite 1D chain. The mononuclear units in 2 are linked through weak N-H…O and C-H…O hydrogen bonds to form an infinite 2D network. The in vitro antitumor activities of ligand and complexes were tested by MTT method, which results show that 1 and 2 have strong in vitro antitumor activity against HEPG2 and SW620 cancer cells lines. CCDC:1041671, 1; CCDC 1041672, 2. |
| Keywords: acylhydrazone complex crystal structure antitumor activity |
| 投稿时间：2016-05-02 修订日期：2016-06-17 |
| 摘要点击次数: 1999 |
| 全文下载次数: 1976 |
| 高平章,陈雅心,郑敏敏,王景梅,解庆范,陈延民.基于一种酰腙和咪唑配体的铜(Ⅱ)、镍(Ⅱ)配合物的水热合成、晶体结构及体外抗癌活性[J].无机化学学报,2016,32(9):1572-1578. |
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