| 由4-甲基-1,2,3-噻二唑-5-甲酸构筑的铜配合物的合成、晶体结构及与DNA作用 |
| Syntheses, Crystal Structures and DNA-Binding of Two Copper(Ⅱ) Complexes Constructed by 4-Methyl-1,2,3-thiadiazol-5-carboxylic Acid |
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| 摘要: 由4-甲基-1，2，3-噻二唑-5-甲酸(HMTC，C4H4N2O2S)和菲咯啉(Phen)合成了2个铜配合物[Cu(MTC)2(H2O)2]n(1)，[Cu2(MTC)2(Phen)2(H2O)4](MTC)2(2)。用元素分析、红外光谱、热重分析、粉末X射线衍射进行表征，用单晶X射线衍射方法测定了配合物的晶体结构。结果表明，配合物1是一维链状结构，属于单斜晶系，P21/c空间群，中心金属铜(Ⅱ)离子的配位构型是一个畸变的四方锥结构。配合物2属于三斜晶系，P1空间群，是一个双核结构，由2个配位水分子上的氧桥连2个铜(Ⅱ)离子形成六配位的扭曲八面体结构。用溴化乙锭荧光探针测定了配体和配合物与DNA的相互作用，结果显示无论是配体还是配合物均能使EB-DNA复合体系的荧光发生不同程度的猝灭，且配合物的作用强度大于配体，具有刚性平面辅助配体的配合物2的作用强度又大于不加辅助配体的配合物1。 |
| 关键词: 铜配合物 4-甲基-1,2,3-噻二唑-5-甲酸 晶体结构 DNA作用 |
| 基金项目: 浙江省公益性技术应用研究计划项目（No.2014C32014）。 |
| Abstract: Two copper complexes[Cu(MTC)2(H2O)2]n (1) and[Cu2(MTC)2(Phen)2(H2O)4](MTC)2 (2) were synthesized by 4-methyl-1,2,3-thiadiazol-5-carboxylic acid(HMTC, C4H4N2O2S) and 1,10-phenanthroline(Phen), and structurally characterized by elemental analysis, IR spectra, TG, PXRD and single crystal X-ray diffraction method. The single crystal X-ray diffraction reveals that the complex 1 formed a 1D chain coordination ploymer and crystallized in monoclinic with space group P21/c. Central Cu2+ was five-coordinated forming a distorted pentahedron coordination geometry. The complex 2 was a binuclear structure, which was bridged by two oxygen atoms from two coordinated water, and crystallized in triclinic with space group P1. Central Cu2+ was six-coordinated forming a distorted octahedron coordination geometry. In addition, the interaction of complexes and ligand with DNA were also studied by ethidium bromide fluorescence probe. The interaction of complex 2 with DNA was stronger than complex 1. |
| Keywords: copper complex 4-methyl-1,2,3-thiadiazol-5-carboxylic acid crystal structure DNA-binding |
| 投稿时间：2016-04-18 修订日期：2016-04-18 |
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| 胡未极,武大令,沈金杯,赵国良.由4-甲基-1,2,3-噻二唑-5-甲酸构筑的铜配合物的合成、晶体结构及与DNA作用[J].无机化学学报,2016,32(8):1467-1475. |
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