| 2,4-二羟基苯甲醛异烟酰腙及其镉配位聚合物的合成、晶体结构和性质 | |
| Syntheses, Crystal Structures and Properties of 2,4-Dihydroxy-benzaldehyde Isonicotinoyl Hydrazone and Its Cd(Ⅱ) Coordination Polymer | |
| 摘要: 合成了一种多齿Schiff碱2，4-二羟基苯甲醛异烟酰腙(H3Ldis·H2O，1)，采用扩散法制备了一种二维镉配位聚合物[Cd2(μ3-HLdis)2(CH2OH)2]n(2)，通过元素分析、光谱分析和X射线单晶衍射对它们进行了表征。结构分析表明1和2的晶体均属单斜晶系，P21/n空间群。1通过分子间氢键形成三维超分子网络。在2中Cd2+处于畸变的八面体配位环境，H3Ldis以烯醇式与镉配位形成双核结构基元，由于吡啶基氮原子配位将双核结构基元扩展为多孔的二维网络结构。MTT法检测结果表明，配合物2对人肝肿瘤HEPG2细胞和人结肠癌细胞均有良好的增殖抑制作用。 | |
| 关键词: 镉配位聚合物 晶体结构 异烟酰腙 抗癌活性 | |
| 基金项目: 福建省教育厅科技类项目（No.JK2015035）和福建省大学生创新创业实践项目（No.201510399025）资助。 | |
| Abstract: A multidentate Schiff base ligand (H3Ldis·H2O, 1), derived from the condensation of 2,4-dihydroxy-benzaldehyde and isoniazide, reacted with cadmium acetate by using diffusion method, which yielded a two-dimension coordination polymer[Cd2(μ3-HLdis)2(CH2OH)2]n(2). The ligand and complex were characterized by elemental analysis, IR, UV spectra and X-ray diffraction analysis. The results show that both 1 and 2 crystallize in monoclinic system, space group P21/n. The compound 1 is linked by intermolecular H-bonds to form three-dimension supramolecular framework. In 2, Cd(Ⅱ) cations in distorted octahedron geometry are coordinated by HLdis2- anions to generate binuclear units which are further linked by pyridinyl nitrogen atoms into a porous network structure. The antitumor activities in vitro ligand and complexes were tested by MTT method, which results show that the complex 2 has good antitumor activity against HEPG2 and SW620 cancer cells with IC50 of 5.7 and 7.8 μg·cm-3, respectively. | |
| Keywords: cadmium coordination polymer crystal structure isonicotinoyl hydrazone antitumor activity | |
| 投稿时间：2016-04-03 修订日期：2016-06-15 | |
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| 陈延民,曾倩茹,李颖,林建宁,王景梅,瞿波,解庆范.2,4-二羟基苯甲醛异烟酰腙及其镉配位聚合物的合成、晶体结构和性质[J].无机化学学报,2016,32(8):1398-1404. | |
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