| Fe3O4/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能 |
| Preparation and Liver MRI of Fe3O4/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent |
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| 摘要: 采用季铵盐化壳聚糖(HTCC)对Fe3O4进行表面改性,成功制备在模拟生理环境中悬浮稳定的超顺磁性Fe3O4/HTCC复合纳米粒。通过动态光散射、透射电镜、振动样品磁强计、磁共振等手段对材料的性能进行表征,并考察了其细胞相容性及磁共振造影性能。结果表明:该方法所制备的超顺磁性复合纳米粒粒径均一,模拟生理环境中具有良好的分散稳定性;体外实验表明该磁性纳米粒具有良好的细胞相容性;大鼠体内肝脏磁共振造影实验表明Fe3O4/HTCC纳米粒注入后,大鼠肝实质信号强度明显下降,因此Fe3O4/HTCC纳米粒有望作为潜在的阴性造影剂应用于肝磁共振造影检测。 |
| 关键词: 季铵盐化壳聚糖 超顺磁性四氧化三铁 分散稳定性 磁共振造影 |
| 基金项目: 国家自然科学基金(No.21201149);江苏省自然科学基金(BK2012259)资助项目。 |
| Abstract: Supermagnetic Fe3O4/N-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan nanoparticles were synthesized by combining Fe3O4 and CS chemically modified with glycidyl trimethyl ammonium chloride. Properties of the obtained nanoparticles were investigated by transmission electron microscopy, dynamic light scattering, magnetic resonance imaging and vibration sample magnetometer. The cytocompatibility of the nanoparticles were assessed. Then the in vivo MRI of the nanoparticles were confirmed. The results demonstrate that the nanoparticles are uniform and stable in simulated physiological environment. Also the nanoparticles show good cyto-compatibility. The in vivo results show that the parenchyma signal intensity of rats liver is significantly decreased after injection of the nanoparticles. Thus it indicates that the nanoparticles have potential application in liver MRI as a negative contrast. |
| Keywords: N-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan supermagnetic Fe3O4 suspension stablility magnetic resonance imaging |
| 投稿时间：2015-03-11 修订日期：2015-06-26 |
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| 宋晓丽,骆夏丹,李凌,朱爱萍.Fe3O4/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能[J].无机化学学报,2015,31(10):1987-1992. |
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