| 生物质碳点的合成及初步用于盐酸土霉素的测定 |
| Biomass-Based Carbon Dots：Synthesis and Application in Oxytetracycline Hydrochloride Determination |
| 作者 | 单位 | E-mail | | 严拯宇 | 药物质量与安全预警教育部重点实验室, 南京 210009
中国药科大学理学院, 分析化学教研室, 南京 210009 | | | 赵娜 | 药物质量与安全预警教育部重点实验室, 南京 210009
中国药科大学理学院, 分析化学教研室, 南京 210009 | | | 刘贞 | 药物质量与安全预警教育部重点实验室, 南京 210009
中国药科大学理学院, 分析化学教研室, 南京 210009 | | | 吕华 | 药物质量与安全预警教育部重点实验室, 南京 210009
中国药科大学理学院, 分析化学教研室, 南京 210009 | | | 陈建秋 | 药物质量与安全预警教育部重点实验室, 南京 210009
中国药科大学理学院, 分析化学教研室, 南京 210009 | cjqercarbon@yeah.net |
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| 摘要: 以活性炭为碳源，过氧化氢和醋酸为混合氧化剂，通过化学氧化法合成了碳点。经过乙醚提取纯化，并用聚乙二醇2000进一步钝化，碳点性能得到了改善。最终制得的碳点在316nm处激发时，最大发射波长出现在435nm左右，其荧光量子产率为19.6%。盐酸土霉素对碳点有猝灭作用，据此实现了对土霉素的测定。该方法线性关系良好(r=0.9986)，回收率在98.0%~102.0%(RSD=1.7%)，检测限达1.4×10-3μg·mL-1。 |
| 关键词: 碳点 聚乙二醇2000 盐酸土霉素 荧光猝灭 |
| 基金项目: 江苏省环境工程重点实验室开放基金(No.KF2012008)；江苏省自然科学基金青年基金(No.BK20130646)；中央高校基本科研业务费专项资金(No.JKQZ2013009，No.JKPZ2013017)；中国药科大学大学生创新训练计划(No.02640556、JKY2011083)资助项目。 |
| Abstract: Carbon dots (CDs) were prepared via a simple chemical oxidation route using activated carbon as the carbon precursor and a mixture of hydrogen peroxide and acetic acid as the oxidant. The obtained CDs were further purified by diethyl ether and passivated by polyethylene glycol 2000 (PEG2000). When excited at 316 nm, the maximum emission wavelength of the CDs is about 435 nm, with a quantum yield of 19.6%. Based on fluorescence quenching, a novel method for assay of oxytetracycline hydrochloride (OTC) was developed with PEG2000-passivated CDs. Alinear relationship between the change of fluorescence intensity and the concentration of OTC (1.66~49.69 μg·mL-1) was obtained with a relation coefficient of 0.9986. The recovery was in the range of 98.0% to 102.0% with a relative standard deviation of 1.7%, and the limit of detection was 1.4×10-3 μg·mL-1. |
| Keywords: carbon dots polyethylene glycol 2000 oxytetracycline hydrochloride fluorescence quenching |
| 投稿时间：2013-08-27 修订日期：2013-11-23 |
| 摘要点击次数: 1980 |
| 全文下载次数: 1910 |
| 严拯宇,赵娜,刘贞,吕华,陈建秋.生物质碳点的合成及初步用于盐酸土霉素的测定[J].无机化学学报,2014,30(4):937-944. |
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