| 2-羧基苯甲醛缩二乙烯三胺钙(Ⅱ)配合物的合成、结构表征和抗肿瘤活性的研究 |
| Synthesis, Structural Characterization and Antitumor Activity of a Ca(Ⅱ)-Schiff Base Complex |
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| 摘要: 在乙醇溶剂中,以高氯酸钙、2-羧基苯甲醛缩二乙烯三胺为原料,合成了一个新型钙配合物。对其进行了元素分析、红外光谱分析、摩尔电导、差热-热重分析,并用X-射线单晶衍射测定了它的单晶结构。结果表明:在配合物分子中,每个钙原子分别与希夫碱配体中的6个氧原子配位,形成了变形的八面体构型。配合物属三方晶系,P31c空间群,配合物分子通过氢键和苯环的π-π堆积作用形成了三维网状结构。初步研究了配合物对肝癌、肺腺癌、白血病和结肠癌的抗肿瘤活性。 |
| 关键词: 2-羧基苯甲醛缩二乙烯三胺 Ca(Ⅱ)配合物 合成 结构表征 抗肿瘤活性 |
| 基金项目: 国家自然科学基金(No.21171132;No.20671073),山东省优秀中青年科学家奖励基金(No.2010BSA07004),潍坊市鸢都学者岗位团队项目
和潍坊市科技发展计划资助项目。 |
| Abstract: A 3D network Ca(Ⅱ) complex has been synthesized in CH3CH2OH solvent, and characterized by elemental analysis, IR spectra, molar conductivity, thermal analysis and X-ray crystal structure determination. The results of crystal structure show that that each Ca(Ⅱ) ion is coordinated with six oxygen atoms from Schiff base ligands (Schiff base derived from 2-carboxybenzaldehyde and diethylenetriamine), forming a distorted octahedral coordination geometry. The compound formed 3D network structure through hydrogen bonds and π-π interaction of benzene rings. The antitumor activity of the Ca(Ⅱ) complex also was investigated. CCDC: 709605. |
| Keywords: 2-carboxybenzaldehyde-diethylenetriamine Ca(Ⅱ) complex synthesis structure characterization antitumor activity |
| 投稿时间：2012-06-17 修订日期：2013-02-01 |
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| 台夕市,赵文华,李法辉.2-羧基苯甲醛缩二乙烯三胺钙(Ⅱ)配合物的合成、结构表征和抗肿瘤活性的研究[J].无机化学学报,2013,29(6):1328-1332. |
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