| 1，10-邻菲咯啉-5，6-二酮铁(Ⅱ)配合物的合成、结构及与DNA相互作用的研究(英文) |
| Synthesis, Crystal Structure and the Interaction with DNA of the Fe(Ⅱ) Complex with Tris-(1,10-phenanthroline-5,6-dione) |
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| 摘要: 在乙腈体系中合成了Fe(Ⅱ)的配合物[Fe(phon)3](ClO3)2·2CH3CN(phon=1，10-邻菲咯啉-5，6-二酮)。X-射线衍射单晶结构表明：配合物[Fe(phon)3](ClO3)2·2CH3CN属于正交晶系，P212121空间群，Fe(Ⅱ)与3个phon配体的6个氮原子配位，形成变形的八面体结构。配合物[Fe(phon)3](ClO3)2·2CH3CN中的氢键和C=O…π相互作用将配合物连接成二维网络结构。用红外光谱、紫外-可见光谱对配合物[Fe(phon)3](ClO3)2·2CH3CN进行了表征，并用紫外光谱法对配合物与ct-DNA的相互作用做了初步研究，结果表明配合物与ct-DNA的结合常数(Kb)为2.2×105 L·mol-1。 |
| 关键词: 1，10-邻菲啰啉-5，6-二酮 铁(Ⅱ)配合物 晶体结构 弱相互作用 ct-DNA |
| 基金项目: |
| Abstract: The crystal structure of the complex [Fe(phon)3](ClO3)22CH3CN (phon=1,10-phenanthroline-5,6-dione) has been determined via the X-ray diffraction method and refined via the full-matrix least-squares methods to R=0.069 1 and wR2=0.143 7 using 4 966 reflections with I>2σ(I). This complex crystallizes in the orthorhombic system, space group P212121 with a=1.381 8(4), b=1.416 7(4), c=2.053 3(6) nm and Z=4. The X-ray analysis revealed that the Fe(Ⅱ) ion is coordinated by the six nitrogen atoms from three ligands in a slightly distorted octahedral arrangement. The C-H…O and C=O…π interactions extend the complex into a quasi 2D networks, and such weak interactions further stabilized the complex. The complex was characterized via FT-IR and UV-Vis. The interaction between the complex and calf thymus DNA was investigated using UV spectra. The intrinsic binding constant (Kb) for the complex to DNA was calculated to be 2.2×105 L·mol-1. CCDC: 672079. |
| Keywords: 1,10-phenanthroline-5,6-dione Fe(Ⅱ) complex crystal structure weak interactions calf thymus DNA |
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| 赵海燕,马晶军,杨芙丽.1，10-邻菲咯啉-5，6-二酮铁(Ⅱ)配合物的合成、结构及与DNA相互作用的研究(英文)[J].无机化学学报,2012,28(11):2468-2472. |
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