| 正十二烷基-L-羟基脯氨酸手性配位萃取拆分外消旋苯丙氨酸 |
| Resolution of D,L-Phenylalaine by Chiral Coordination Extraction with n-Dodecyl-L-hydroxyproline |
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| 摘要: 本文合成新手性配体正十二烷基-L-羟基脯氨酸，研究手性配体正十二烷基-L-羟基脯氨酸与Cu(Ⅱ)配位萃取拆分苯丙氨酸的性能和机理，考察起始氨基酸浓度、配位铜离子浓度、萃取剂浓度、溶液pH值及温度等因素分别对D-和L-苯丙氨酸萃取性能的影响，萃取剂对D-苯丙氨酸的识别能力强。利用多种手段对萃合物的组成进行表征，推测萃合物的结构为1∶1∶1型三元配合物。对比发现：该萃取剂配位萃取拆分苯丙氨酸性能优于正辛基-L-羟基脯氨酸，空间位阻效应反而对拆分有利。 |
| 关键词: 正十二烷基-L-羟基脯氨酸 手性配体 萃取拆分 D/L-苯丙氨酸 |
| 基金项目: |
| Abstract: The novel chiral extractant n-dodecyl-L-hydroxyproline was synthesized. The resolution of D,L-phenylalaine by chiral coordination extraction with n-Dodecyl-L-Hydroxyproline and Cu(Ⅱ) was studied. The effect of the initial aqueous phenylalanine concentration, concentrations of copper ion and extractant, pH and extraction temperature on the extraction distribution of D,L-phenylalaine were investigated. The extractant showed better affinity for D-phenylalaine. The extracted species were characterized and the stoichiometry was suggested to be 1∶1∶1 to form a ternary complex. The results showed that the resolution efficiency with n-Dodecyl-L-Hydroxyproline is better than that with n-octyl-L-Hydroxyproline, which indicated that n-dodecyl with its bigger steric effect favors the separation of D,L-phenylalanine compared with the smaller n-octyl group. |
| Keywords: n-dodecyl-L-hydroxyproline chiral ligand extraction resolution D/L-phenylalanine |
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| 崔 玉,孙国新,田晓强,夏光明,公佩欣.正十二烷基-L-羟基脯氨酸手性配位萃取拆分外消旋苯丙氨酸[J].无机化学学报,2012,28(4):686-690. |
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