| 以N-(2-羟苄基)-DL-缬氨酸及4，4′-联吡啶为配体的铜(Ⅱ)配合物的合成、晶体结构及抑菌活性 | |
| Synthesis, Crystal Structure and Antibacterial Activity of Copper(Ⅱ) Complex Containing N-(2-hydroxybenzyl)-DL-valine and 4,4′-Bipyridine | |
| 摘要: 合成了一个化合物[Cu(sval)(4，4′-bipy)](sval=N-(2-羟苄基)-DL-缬氨酸阴离子，4，4′-bipy=4，4′-联吡啶)，通过元素分析、红外光谱、X-射线单晶衍射及热重分析对其进行了结构表征。晶体属单斜晶系，空间群P21/c，晶胞参数:a=1.087 23(19) nm，b=1.360 1(2) nm，c=1.359 6(2) nm，β=105.433(2)°，Z=2，V=1.938 0(6) nm3，μ=1.157 mm-1，Dc=1.511 g·cm-3，F(000)=916，R1=0.033 2，wR2=0.089 1。配合物中Cu(Ⅱ)为四配位的平面四边形配位构型，该配合物通过π-π堆积和Cu…N弱相互作用形成双核结构单元，相邻双核结构单元通过Cu…O弱相互作用形成了一个一维链状结构。初步的生物活性实验表明配合物与配体相比，配合物的抑菌活性显著提高。 | |
| 关键词: N-(2-羟苄基)-DL-缬氨酸 4，4′-联吡啶 铜配合物 晶体结构 抑菌活性 | |
| 基金项目: | |
| Abstract: A compound [Cu(sval)(4,4′-bipy)] (sval=N-(2-hydroxybenzyl)-DL-valinate, 4,4′-bipy=4,4′-bipyridine) was synthesized and characterized by elemental analysis, IR, X-ray crystal diffraction and thermogravimetric analysis. It crystallizes in monoclinic system with space group P21/c. The crystal data are: a=1.087 23(19) nm, b=1.360 1(2) nm, c=1.359 6(2) nm, β=105.433(2)°, Z=2, V=1.938 0(6) nm3, μ=1.157 mm-1, Dc=1.511 g·cm-3, F(000)=916, R1=0.033 2, wR2=0.089 1. In the title complex, neutral Cu(Ⅱ) ion is four coordinated with distorted square planar geometry. The complex formed the dimeric unit through π-π stacking and Cu…N weak interactions. Every two adjacent dimeric units are linked by Cu…O weak interactions to generate a one-dimensional chain. The preliminary biological activity tests showed that antibacterial activity of the complex was significantly improved. CCDC: 855040. | |
| Keywords: N-(2-hydroxybenzyl)-DL-valine 4,4′-bipyridine Cu(Ⅱ) complex crystal structure antibacterial activity | |
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| 胡久荣,闫卫红,郑大贵,叶红德,饶 敏.以N-(2-羟苄基)-DL-缬氨酸及4，4′-联吡啶为配体的铜(Ⅱ)配合物的合成、晶体结构及抑菌活性[J].无机化学学报,2012,28(3):531-535. | |
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