| 二吡啶甲基胺配合物修饰的肿瘤靶向性硅核壳纳米球(英文) |
| Target Cancer Cells through Complexes of Di(picolyl)amine Modified Silica Core-Shell Nanospheres |
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| 摘要: 运用油包水微乳液方法制备了二吡啶甲基胺(dpa)及其锰(Ⅱ)和铁(Ⅲ)配合物修饰的Gd-DTPA配合物硅核壳纳米球，其中二吡啶甲基胺锰(Ⅱ)和铁(Ⅲ)配合物修饰的纳米球粒径分别为60和5 nm。体外MRI成像研究表明3种纳米球能显著提高肿瘤细胞的磁共振成像效果，具备良好的肿瘤靶向性。生物活性数据显示三价铁配合物修饰的纳米球具备成像和抑制细胞生长的双重功能，而锰配合物修饰的纳米球不能抑制肿瘤细胞的生长，可作为低毒性的肿瘤成像剂。实验结果显示肿瘤靶向性配合物修饰的纳米球可发展成为新型多功能肿瘤靶向性纳米药物。 |
| 关键词: 核壳纳米球 配合物 二吡啶甲基胺 肿瘤 |
| 基金项目: |
| Abstract: Di(picolyl)amine modified silica nanoparticles were prepared by W/O microemulsion method. The coordination of metal ions (Mn(Ⅱ) and Fe(Ⅲ)) with di(pycolyl)amine modified nanoparticles produced two different size of nanospheres with the hydrodynamic diameter of approximately 60 nm and 5 nm, respectively. Three grafted silica nanospheres all display a great contrast enhancement in vitro indicating that they could accumulate in cancer cell, selectively. The Fe(Ⅲ)-di(picolyl)amine complex modified nanosphere was a multifunctional nanoparticle to image and inhibit the proliferation of cancer cells, and Mn(Ⅱ)-di(picolyl)amine complex modified nanosphere could only be used as a low toxic MRI agents. So antitumor complexes modified nanospheres would be new kinds of multifunctional nanoparticles to target the cancer cells actively through complex induced active intracellular accumulating. |
| Keywords: core-shell nanosphere complex, di(picolyl)amine cancer |
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| 陈秋云,王玲昀,陈 浩,王 娟,高 静.二吡啶甲基胺配合物修饰的肿瘤靶向性硅核壳纳米球(英文)[J].无机化学学报,2010,26(10):1784-1789. |
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