| 新型三元铜配合物的合成、晶体结构及与DNA的相互作用 |
| Synthesis, Crystal Structure of A New Ternary Copper(Ⅱ) Complex and Its Interaction with DNA |
|
| 摘要: 合成了一种新型的三元铜配合物[Cu(Dppz)(Gly)(H2O)]·NO3·H2O，(Dppz为二吡啶并[3，2-a；2′，3′-c]吩嗪，Gly为L-甘氨酸)。该配合物晶体属于单斜晶系，P21/c空间群，a=2.158 8(4) nm，b=0.721 6(13) nm，c=1.421 9(3) nm，β=108.648(2)°。配合物分子中五配位的中心金属铜离子处于变形四方锥配位环境。紫外吸收光谱与荧光光谱分析表明，该配合物通过嵌入模式与DNA结合，并在还原剂存在下能显著的切割超螺旋DNA。 |
| 关键词: 二吡啶并[3，2-a 2′，3′-c]吩嗪 三元铜配合物 DNA结合 DNA切割 |
| 基金项目: |
| Abstract: A new ternary copper(Ⅱ) complex, [Cu(Dppz)(Gly)(H2O)]·NO3·H2O (dppz=dipyrido[3,2-a:2′,3′-c]phenazine, Gly=L-glycine), has been synthesized and structurally characterized. The complex crystallized in a monoclinic system with space group P21/c, a=2.158 8(4) nm, b=0.721 6(13) nm, c=1.421 9(3) nm, β=108.648(2)°. The five-coordinate copper(Ⅱ) center is a distorted square pyramid. Absorption spectra and fluorescence spectra showed that there was interaction between the copper(Ⅱ) complex and DNA through an intercalative mode. The complex exhibited efficient DNA cleavage activity in the presence of ascorbate. CCDC: 767873. |
| Keywords: dppz ternary copper(Ⅱ) complex DNA binding DNA cleavage |
| |
| 摘要点击次数: 1456 |
| 全文下载次数: 2242 |
| 周建良,春晓改,周琳姣,陈 云,张寿春.新型三元铜配合物的合成、晶体结构及与DNA的相互作用[J].无机化学学报,2010,26(4):645-650. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: |
|
|
|
|
|
|
