| 氨基酸席夫碱镍、钴配合物的合成、晶体结构与抑菌活性 |
| Synthesis, Crystal Structures and Antibacterial Activities of Ni(Ⅱ), Co(Ⅱ) Complexes from Amino Acid Schiff Base |
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| 摘要: 合成了1-苯基-3-甲基-4-对氯苯甲酰基-5-吡唑啉酮缩L-苯丙氨酸甲酯Schiff碱Ni(Ⅱ)、Co(Ⅱ)配合物[NiL2](CH3OH) (1)和[CoL2](CH3OH) (2)。用元素分析、红外光谱和X-射线单晶结构进行了表征，配合物1和2的晶体结构都同时含有两个独立子单元及一个游离的甲醇分子，各子单元都形成六配位的八面体结构。采用琼脂扩散法测定了配体和配合物对大肠杆菌、金黄色葡萄球菌抗菌活性，结果表明配合物2对大肠杆菌的抑制作用最强。 |
| 关键词: 氨基酸 席夫碱 配合物 晶体结构 抑菌活性 |
| 基金项目: |
| Abstract: Two complexes [NiL2](CH3OH)(1) and [CoL2](CH3OH)(2) were synthesized, where L is a Schiff base ligand (C27H24ClN3O3) was derived from condensation of 1-phenyl-3-methyl-4-(p-chlorbenzyl)-5-pyrazolone with L-Phenylalanine methyl ester. They were characterized by elemental analysis, IR and single crystal X-ray diffraction. The complexes 1 and 2 consist of two individual fragments and a dissociative methanol. Every fragment is a distorted octahedron with four oxygen atoms and two nitrogen atoms. The Schiff base ligand and its complexes have been tested in vitro to evaluate their antibacterial activity against bacteria Escherichia Coli and Staphylococcus Aureus. It has been found that the complex 2 has higher activity than the corresponding free Schiff base ligand and complex 1 against the same bacteria. CCDC: 759690, 1; 759691, 2. |
| Keywords: amino acid Schiff base complex crystal structure antibacterial activity |
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| 张 欣,杜 聪,陈 丹,黄 萌.氨基酸席夫碱镍、钴配合物的合成、晶体结构与抑菌活性[J].无机化学学报,2010,26(3):489-494. |
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