| 奈达铂的新合成方法、晶体结构和热稳定性 | |
| Synthesis, Crystal Structure and Thermal Stability of A Platinum-Based Anti-Tumour Drug Nedaplatin | |
| 摘要: 本文报道了铂族金属抗癌药物奈达铂的一种新合成方法，产率约65%，精品含量超过99%。采用了元素分析、红外光谱、质谱、差热-热重分析和X射线衍射手段对其结构和组成进行了表征。该配合物的晶体属正交晶系，空间群P212121。单晶X射线衍射结构分析结果表明铂(Ⅱ)离子与2个氨分子的氮原子以及乙醇酸羟基和羧基的氧原子配位，形成平面正方形结构，乙醇酸的二价阴离子通过羟基和羧基上的氧原子与铂(Ⅱ)离子配位形成五原子的螯合物。经TG-DTA | |
| 关键词: 奈达铂 合成 晶体结构 热稳定性 | |
| 基金项目: | |
| Abstract: The nedaplatin has been synthesized by a new technique, the yield rate is about 65%, the content of pure product is above 99%. Its structure was characterized by elemental analysis, IR, MS, thermal analysis and X-ray diffraction single crystal structure analysis. Its crystal belongs to orthorhombic space group P212121 with a=0.562 93(6) nm, b=0.728 53(8) nm, c=1.411 07(16) nm. The PtⅡ atom is coordinated by two N atoms of ammine and two O atom of carboxyl group and hydroxy, forming a sqare-planar environment. The glycolate dianion forms a five-membered chelate ring, coordinating to the Pt(Ⅱ) ion not only at an O atom of the carboxyl group but also at the hydroxy. The results of TG-DTA analysis show that the nedaplatin was stable under 180 ℃. CCDC: 706387. | |
| Keywords: nedaplatin synthesis crystal structure thermal stability | |
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| 王庆琨,普绍平,丛艳伟,侯树谦,李永年,何 键,栾春芳.奈达铂的新合成方法、晶体结构和热稳定性[J].无机化学学报,2009,25(8):1375-1378. | |
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