| 支链/环链烷氧基乙酸为离去配体的铂(Ⅱ)配合物的体外活性研究(英文) |
| In vitro Cytotoxicity Activity of Platinum(Ⅱ) Complexes with Alkyl-branched/Cyclic Alkoxyacetates as Leaving Ligands |
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| 摘要: 合成了12个带支链/环链烷氧基乙酸为离去基团的顺铂类配合物，通过元素分析、红外光谱、核磁共振氢谱和质谱对配合物进行了表征。研究了所有化合物对人非小细胞肺癌A549、人肝癌细胞BEL-7402和人乳腺癌细胞MCF-7细胞系的体外抗肿瘤活性。测试结果表明，12个配合物中有5个对人乳腺癌细胞系MCF-7有较好的体外活性。其中化合物2(顺-二(异丙氧基乙酸根)·二氨合铂(Ⅱ))在所有的化合物中显示最高的活性，对所测3个细胞系都是如此。 |
| 关键词: 铂(Ⅱ)配合物 抗肿瘤活性 支链烷氧基乙酸根 |
| 基金项目: |
| Abstract: Twelve cisplatin-typed platinium complexes containing alkyl-branched alkoxyacetates and cyclic alkoxyacetates as leaving groups were prepared and characterized by elemental analysis, infrared, electro-spray ionization MS and 1H NMR spectroscopy. All compounds were evaluated for their in vitro cytotoxicity against A549 human non-small-cell lung cancer, BEL-7402 human hepatocellular carcinoma and MCF-7 human breast cancer cell lines, respectively. 5 out of 12 complexes with alkyl-branched alkoxyacetates showed good cytotoxicity against MCF-7 cell line. Complex 2{cis-(diammine)bis(t-butoxyacetate)platinum(Ⅱ)} showed the highest cytotoxicity against all the three cell lines. |
| Keywords: Pt (Ⅱ) complexes anti-tumor activity alkyl-branched alkoxycarboxylates |
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| 刘 霞,苟少华,沈 宏,诸海滨,郑和根.支链/环链烷氧基乙酸为离去配体的铂(Ⅱ)配合物的体外活性研究(英文)[J].无机化学学报,2009,25(4):700-707. |
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