| 配体结构对NAMI-A衍生物水解机理、速度的影响 |
| Influence of Ligand Structure on the Hydrolytic Mechanism and Rate of NAMI-A Derivatives |
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| 摘要: 制备并用紫外-可见分光光度法研究了trans-[RuCl4(DMSO)(N-EtIm)][(N-EtIm)H](N-EtIm=N-乙基咪唑)(化合物1)在pH=7.40及5.00，0.15 mol·L-1 NaCl，37 ℃溶液中的水解机理及动力学。化合物1在pH=7.40的缓冲溶液中发生两步水解脱氯反应(Ⅰ氯水解及Ⅱ氯水解)(分步反应)，最终溶液颜色变深形成聚合物。在pH=5.00缓冲溶液中二甲基亚砜(DMSO)水解。其Ⅰ氯、Ⅱ氯水解及DMSO水解反应皆为零级反应。测定了各水解反应表观速率常数Kobs及半衰期t1/2。化合物1的Ⅰ氯及Ⅱ氯水解反应与NAMI-A相似，而且各水解速度也相差不大，即将推电子的乙基引入咪唑环，对NAMI-A的Ⅰ氯、Ⅱ氯及DMSO水解反应速度影响较小。化合物在酸性溶液中的稳定性明显高于中性溶液。 |
| 关键词: 钌化合物 抗转移 水解动力学 稳定性 |
| 基金项目: |
| Abstract: trans-[RuCl4(DMSO)(N-EtIm)][(N-EtIm)H](N-EtIm=N-ethylimidazole) (compd. 1) was prepared, its hyd-rolytic mechanism and kinetics were studied by UV-Vis spectroscopy at pH=7.40/5.00, 0.15 mol·L-1 NaCl, 37 ℃. Compd. 1 undergoes two well-separated steps of chloride hydrolysis at pH=7.40, while dimethyl sulfoxide (DMSO) hydrolyzed in pH=5.00 buffer solution. All the hydrolysis follows the zero order reaction. The Kobs and t1/2 for each reaction were determined. The hydrolytic rate of compd. 1 including 2 chlorides and DMSO hydrolysis are similar to that of NAMI-A, which demonstrates that the influence of introducing ethyl group into imidazole ring is small on the hydrolysis rate of NAMI-A derivatives. The stability of compd. 1 in acidic solution is much more stable than that of in neutral solution. |
| Keywords: ruthenium complexes anti-metastasis hydrolytic kinetics stabilities |
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| 摘要点击次数: 1273 |
| 全文下载次数: 1913 |
| 梁曜华,梁国刚.配体结构对NAMI-A衍生物水解机理、速度的影响[J].无机化学学报,2008,24(12):1983-1988. |
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