| 吡啶-3-甲醛缩氨基硫脲合镍(Ⅱ)、锌(Ⅱ)配合物的合成、晶体结构及生物活性(英文) |
| Synthesis, Crystal Structures, and Bioactivities of NiⅡ and ZnⅡ Complexes with Pyridine-3-carbaldehyde Thiosemicarbazone |
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| 摘要: 本文合成并表征了吡啶-3-甲醛缩氨基硫脲(HL)合镍(Ⅱ)、锌(Ⅱ)配合物。在配合物[NiL2] (1)中，镍(Ⅱ)离子与来自2个脱氢配体的2个氮原子和2个硫原子配位，形成四配位的平面正方形构型。在配合物[Zn(HL)2(C2H5OH)2(H2O)2](NO3)2 (2)中，锌(Ⅱ) |
| 关键词: 镍Ⅱ配合物 锌Ⅱ配合物 氨基硫脲 DNA作用 抗菌活性 |
| 基金项目: |
| Abstract: The NiⅡ and ZnⅡ complexes with pyridine-3-carbaldehyde thiosemicarbazone(HL) have been synthesized and characterized by X-ray diffraction. In the [NiL2] (1), the NiⅡ atom was four-coordinated to form a square geometry by two nitrogen atoms and two sulfur atoms from two different deprotonated ligands. In [Zn(HL)2(C2H5OH)2(H2O)2](NO3)2(2), the ZnⅡ atom was in a distorted octahedral geometry coordinated by two neutral ligands, two ethanol molecules, and two water molecules. The binding of the two complexes with calf thymus DNA has been investigated by absorption, luminescence titrations. The results suggest that both the two complex intercalates into DNA base pairs. Antimicrobial activities of the free ligand and the two complexes against Staphylococcus Aureus, β-hemolytic streptococcus, Streptococcus Pneumoniae, Bacillus Anthracis shows that the free ligand and 1 did not inhibit the growth of the test microorganisms and 2 showed weak activities against the three former tested microorganisms. CCDC: 288409, 1; 288410, 2. |
| Keywords: NiⅡ complex ZnⅡ complex thiosemicarbazone DNA binding antimicrobial activities |
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| 边贺东,李春英,梁宇宁,郭桂全,于青,梁宏.吡啶-3-甲醛缩氨基硫脲合镍(Ⅱ)、锌(Ⅱ)配合物的合成、晶体结构及生物活性(英文)[J].无机化学学报,2008,24(4):527-533. |
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