无机化学学报

1-乙基-6-氟-1，4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸-铜(Ⅱ)-多吡啶配合物的合成、表征及与DNA作用

Four Copper(Ⅱ) Complexes with 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic Acid and Polypyridyl: Synthesis, Characterization and Interaction with DNA

作者	单位
张军军	华南农业大学应用化学系，广州 510642
乐学义	华南农业大学应用化学系，广州 510642

摘要: 合成了4个新的诺氟沙星(NFA)-铜(Ⅱ)-多吡啶配合物：[Cu(NFA)(phen)(H₂O)](ClO₄)₂ (1)，[Cu(NFA)(tatp)(H₂O)](ClO₄)₂ (2)， [Cu(NFA)(dppz)(H₂O)](ClO₄)₂·H₂O (3)和[Cu(NFA)(n-phen)(H₂O)](ClO₄)₂ (4)[NFA=1-乙基-6-氟-1，4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸，phen=1，10-邻菲咯啉，tatp=1，4,8,9-四氮三联苯，dppz=二吡啶并[3，2-a；2′，3′-c]吩嗪，n-phen=5-硝基-1，10-邻菲咯啉]。用元素分析、摩尔电导率、红外光谱及紫外可见光谱对配合物进行了表征，推测了配合物的可能结构。应用紫外光谱、荧光光谱及粘度测定方法研究了配合物与CT-DNA的作用，发现这些配合物均以插入方式与CT-DNA作用。采用打孔法研究了配合物的抗菌活性，结果表明配合物对耻垢分枝杆菌(M.smegmayis)有良好的抑制作用。

关键词: 铜(Ⅱ)配合物诺氟沙星多吡啶 DNA 抗菌活性

基金项目:

Abstract: Four new complexes: [Cu(NFA)(phen)(H₂O)](ClO₄)₂ (1), [Cu(NFA)(tatp)(H₂O)](ClO₄)₂ (2), [Cu(NFA)(dppz)(H₂O)](ClO₄)₂·H₂O (3) and [Cu(NFA)(n-phen) (H₂O)](ClO₄)₂ (4) (NFA=1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid (Norfloxacin), phen=1,10-phenanthroline, tatp=1,4,8,9-tetraazatniphen-ylene, dppz=dipyrido[3,2-a; 2′,3′-c]phenazine, and n-phen=5-nitro-1,10-phenanthroline), were synthesized and character-ized by elemental analysis, molar conductivity, IR and UV-Vis spectroscopes. The interaction between the complexes and CT-DNA was also studied by electronic absorption spectroscopy, ethidium bromide(EB) fluorescence spectroscopy, and viscosity measurements. In addition, the complexes were assayed against M.smegmayis by punch method.

Keywords: copper(Ⅱ) complexes Norfloxacin polypyridyl DNA antibacterial activities

摘要点击次数: 1471

全文下载次数: 1970

张军军,乐学义.1-乙基-6-氟-1，4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸-铜(Ⅱ)-多吡啶配合物的合成、表征及与DNA作用[J].无机化学学报,2008,24(2):175-180.

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