| 铜(Ⅱ)-N-(2-羟苄基)-DL-α-苯丙氨酸-2，2′-联吡啶(或1，10-邻菲咯啉)三元配合物的合成、晶体结构及抑菌活性 |
| Synthesis, Crystal Structure and Bacteriostatic Activity of Ternary Complexes of Copper(Ⅱ) with N-(2-hydroxybenzyl)-DL-α-phenylalanine and 2,2′-bipyridine or 1,10-phenanthroline |
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| 摘要: 合成了铜(Ⅱ)与N-(2-羟苄基)-DL-α-苯丙氨酸(H2sphe)和2，2′-联吡啶(2，2′-bipy)及1，10-邻菲咯啉(phen)的三元配合物 [Cu(Hsphe)(phen)](ClO4)·3H2O (1)、[Cu(Hsphe)(2，2′-bipy)](ClO4) (2)、[Cu(Hsphe)(2，2′-bipy)](NO3) (3)。用X射线单晶衍射测定了配合物的晶体结构。3种配合物中Cu(Ⅱ)离子配位数均为5，处于变形四方锥配位环境中。抑菌活性试验结果表明，3种配合物均对金黄色葡萄球菌、铜绿假单胞菌和枯草杆菌有一定的抑制作用。配合物1还对大肠杆菌、伤寒杆菌有较强的抑制作用，而配合物3对伤寒杆菌亦有一定的抑制作用。 |
| 关键词: N-(2-羟苄基)-DL-α-苯丙氨酸 铜配合物 晶体结构 抑菌活性 |
| 基金项目: |
| Abstract: Ternary complexes of copper(Ⅱ) with N-(2-hydroxybenzyl)-DL-α-phenylalanine (H2sphe) and 2,2′-bipyridine or 1,10-phenanthroline, [Cu(Hsphe)(phen)](ClO4)·3H2O (1), [Cu(Hsphe)(2,2′-bipy)](ClO4) (2), and [Cu(Hsphe)(2,2′-bipy)](NO3) (3) were synthesized and their crystal structures were determined by X-ray diffraction method. The central Cu(Ⅱ) ions in the three complexes are all five-coordinated in distorted square pyramidal geometry. The results of bacteriostatic test show that all three complexes exhibit activity against S. aureus, P. aeruginosa and B. subtilis. In addition, complex 1 shows strong bacteriostatic activity against E. coli and S. typhi, and complex 3 shows activity against S. typhi. CCDC: 619219, 1; 619220, 2; 619221, 3. |
| Keywords: N-(2-hydroxybenzyl)-DL-α-phenylalanine copper(Ⅱ) complex crystal structure bacteriostatic activity |
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| 胡久荣,梁福沛,陈自卢,黄世稳,黄衍强.铜(Ⅱ)-N-(2-羟苄基)-DL-α-苯丙氨酸-2，2′-联吡啶(或1，10-邻菲咯啉)三元配合物的合成、晶体结构及抑菌活性[J].无机化学学报,2006,22(11):1989-1995. |
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