| 金属离子对过亚硝酸根损伤酪氨酸的影响 |
| Influence of Metallic Ions on Tyrosine Modification by Peroxynitrite |
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| 摘要: |
| 关键词: 过亚硝酸根 L-酪氨酸 3-硝基酪氨酸 二聚酪氨酸 金属离子 |
| 基金项目: |
| Abstract: NO· and ·O2- combine each other to form peroxynitrite (ONOO-) in vivo. Peroxynitrite is very cytotoxic, and it damages many biomolecules. 3-nitrotyrosine and dityrosine are two main products from the reaction of ONOO- and tyrosine. Lots of metallic ions in vivo influence the modification of tyrosine by peroxynitrite. UV-Vis and Fluorescence spectrophotometer were used to study the catalysis and inhibition of metallic ions on the production of 3-nitrotyrosine and dityrosine in vitro. Present results showed that Co(Ⅱ), Cu(Ⅱ) and Mn(Ⅱ) enhance the production of 3-nitrotyrosine, and among them Co(Ⅱ) and Mn(Ⅱ) have been reported rarely before about it. In addition, Mn(Ⅱ) inhibits the production of dityrosine to a certain extent. |
| Keywords: peroxynitrite L-tyrosine 3-nitrotyrosine dityrosine metallic ions |
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| 张伟,罗云敬,王云海,钟儒刚.金属离子对过亚硝酸根损伤酪氨酸的影响[J].无机化学学报,2006,22(6):1113-1117. |
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