| 可降解自固化类骨磷灰石支架的研究 | |
| Study on Biodegradable Scaffold of Self-hardening Bone-like Apatite | |
| 摘要: | |
| 关键词: 骨修复 类骨磷灰石 多孔支架 生物降解性 | |
| 基金项目: | |
| Abstract: A novel biodegradable bone repair biomaterial of bone-like carbonated apatite with porous structure was prepared by using self-hardening calcium phosphate cement. Cell culture, degradation in simulated body liquid (SBF) and as a carrier for bone morphogenic protein (BMP) controllable releasing experiments were performed to evaluate the biocompatibility, degradation and BMP carrier properties of the porous scaffold. The results reveal that the degradation property of the carbonated apatite is better than hydroxyapatite, the more the content of CO32- in apatite, the faster the degradation of the materials, the cell could attach, proliferate and differentiate on the porous scaffold, indicating that the bone like apatites not only have excellent biocompatibility but are also biodegradable and can be used as carriers for BMP controlling release. | |
| Keywords: bone repair bone-like apatite porous scaffold biodegradation | |
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| 魏 杰,刘昌胜,洪 华,袁 媛,陈芳萍.可降解自固化类骨磷灰石支架的研究[J].无机化学学报,2006,22(4):765-770. | |
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