| 双(三有机锡)2，3-吡啶二甲酸酯的合成、表征和体外抗癌活性 |
| Synthesis, Characterization and In Vitro Antitumor Activity of Bis(triorganotin) 2,3-Pyridinedicarboxylates |
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| 摘要: 合成了2个新的双(三有机锡)2，3-吡啶二甲酸酯2，3-C5H3N(CO2SnR3)2 (R=c-C6H11，1；C6H5C(CH3)2CH2，2)，利用元素分析、IR和1H NMR表征了其结构。通过X-射线单晶衍射测定了配合物2的晶体结构。该化合物晶体属单斜晶系，空间群P21/n，a=0.955 3(1)，b=1.811 8(2)，c=3.533 9(4) nm，β=94.914(2)°，Z=4，V=6.094 1(13) nm3，R=0.038 4，wR=0.096 6，S=1.015。2，3-吡啶二甲酸的2个羧基键连2个三有机锡，2个锡原子均为畸变的四面体配位构型。生物活性测试结果表明，化合物1和2对3种人癌细胞HeLa、CoLo205和MCF-7具有好的体外抗癌活性。 |
| 关键词: 有机锡羧酸酯 2，3-吡啶二甲酸 体外抗癌活性 晶体结构 |
| 基金项目: |
| Abstract: The bis(triorganotin) 2,3-pyridinedicarboxylates, 2,3-C5H3N(CO2SnR3)2 (R=c-C6H11，1；C6H5C(CH3)2CH2，2), have been prepared and characterized by elemental analysis, IR and 1H NMR spectroscopes. The crystal structure of 2 has been determined. The crystal belongs to monoclinic space group P21/n with a=0.955 3(1), b=1.811 8(2), c=3.533 9(4) nm, β=94.914(2)°, Z=4, V=6.094 1(13) nm3, R=0.038 4, wR=0.096 6, S=1.015. In the compound, the 2,3-pyridinedicarboxylate dianion binds two triorganotin entities and both tin atoms exist respectively in a distorted tetrahedral environment. Bioassay results have shown that the compounds possess good in vitro antitumor activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7. CCDC: 292264. |
| Keywords: organotin carboxylate 2,3-pyridinedicarboxylic acid in vitro antitumor activity crystal structure |
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| 摘要点击次数: 1522 |
| 全文下载次数: 1922 |
| 田来进,孙玉希,郑晓亮,刘西成,钱伯初.双(三有机锡)2，3-吡啶二甲酸酯的合成、表征和体外抗癌活性[J].无机化学学报,2006,22(4):629-632. |
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