| 新型双核铜配合物的结构及DNA切割活性 | |
| A Novel Dinuclear Copper Complex with Potent Nuclease Activity | |
| 摘要: 合成了一种以吡啶-2,6-二甲酸(dipicH2)桥联的新型双核邻菲咯啉铜配合物，[Cu2(phen)3(dipic)(OH)]·Na·ClO4·2H2O(phen 为1，10-菲咯啉的缩写)。该配合物晶体属于单斜晶系，P21/n空间群，a=1.225 85(2) nm，b=2.196 3(3) nm，c=1.619 5(2) nm，β=100.951(2)°。配合物分子中的两个中心铜离子均处于变形的四方锥配位环境，并通过吡啶-2，6-二甲酸配体上的氧氮原子相连。凝胶电泳结果表明，在pH 7.4，温度37 ℃，以抗坏血酸为还原剂或在H2O2的存在下，该配合物对超螺旋pBR322 DNA表现出显著的切割活性，为人工金属核酸酶的研究提供了新的例证。 | |
| 关键词: 双核配合物 铜配合物 晶体结构 DNA切割 | |
| 基金项目: | |
| Abstract: A novel dinuclear copper complex, [Cu2(phen)3(dipic)(OH)]·Na·ClO4·2H2O (phen=1,10-phenanthroline, dipicH2=2,6-pyridinedicarboxylic acid), has been synthesized and structurally characterized. The complex crystallized in a monoclinic system with space group P21/n, a=1.225 85(2) nm, b=2.196 3(3) nm, c=1.619 5(2) nm, β=100.951(2)°. The two copper ions are bridged by the dipic ligand and both are situated in a distorted square-pyramidal geometry. The complex exhibited efficient DNA cleavage activity at micromolar concentration in the presence of ascorbate or H2O2. This work provides a novel example for the design of metallo-nuclease. CCDC: 247064. | |
| Keywords: dinuclear copper complex crystal structure DNA cleavage | |
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| 张寿春,邵 颖,涂 超,戴春晖,郭子建.新型双核铜配合物的结构及DNA切割活性[J].无机化学学报,2004,20(10):1159-1164. | |
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