| 新型胺羧单酯-酰胺钆配合物的合成及其对大鼠肝区T1弛豫增强作用 | |
| Synthesis and MRI Relaxation Enhancement of Mono-exter-amido Gadolinium Complexes | |
| 摘要: 通过DTPA、EDTA单活化酯与双乳酸酰乙二胺二醇、双乳酸酰己二胺二醇反应，合成了四种新型胺羧单酯-酰胺配体及其钆配合物。表征了配体和配合物的结构，测定了钆配合物水溶液水质子的弛豫效能。选取其中一个配合物进行了动物急性毒性测试和活体T1加权成像实验。结果表明：该配合物无明显急性毒性，且对大鼠肝区质子有明显的增强。 | |
| 关键词: 酯-酰胺 钆配合物 肝靶向造影剂 弛豫效能 T1加权磁共振成像 | |
| 基金项目: | |
| Abstract: Four new ester-amido ligands were synthesized by esterification of mono-iso-butyl diethylenetriaminepentaacetate and mono-iso-butyl ethylenediaminetetraacetate with N,N′-ethylene bis-lactamide and N,N′-1,6-hexamethylenebislactamide, respectively. The corresponding Gd(Ⅲ) complexes were made by reacting the ligands with Gd2O3. All ligands and complexes were characterized by FT-IR, 1H NMR and elemental analysis. The measured longitudinal relaxivity of these complexes were all higher than that of Gd-DTPA. The investigation on cute toxicity and T1-weighted imaging of complex derived from mono-N,N′-ethylenebislactamide ester diethlenetriaminepentaacetate were performed. No cute toxicity was found. The tested complex exhibited the higher enhancement on MRI signal intensity in rat liver, comparing with Gd-DTPA. | |
| Keywords: ester-amid gadolinium complex liver-selecting contrast agent relaxivity T1-weighted imaging | |
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| 俞开潮,万福贤,张 焱,周锦兰,卢 广,刘买利,丁尚武.新型胺羧单酯-酰胺钆配合物的合成及其对大鼠肝区T1弛豫增强作用[J].无机化学学报,2004,20(4):389-393. | |
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