| Co(phen)33+与6-巯基嘌呤及DNA间相互作用的研究 |
| Studies on the Interaction among Co(phen)33+, 6-Mercaptopurine and DNA |
|
| 摘要: |
| 关键词: 6-巯基嘌呤 Co(phen)33+ DNA 相互作用 |
| 基金项目: |
| Abstract: The interaction among Co(phen)33+, 6-Mercaptopurine(6-MP) and calf thymus DNA has been investigated using cyclic voltammetry, differential pulse voltammetry and UV-spectra in Tris buffer solutions(pH=7.2). In the presence of 6-MP, the redox peak current at 0.15 V for the central cobalt ion from voltammograms is significantly reduced compared with that in the absence of 6-MP and the current of a new quasi-reversible redox wave shown at -0.06 V gradually increases with 6-MP addition. However, when DNA is further added, the peak current at 0.15 V is renewedly enlarged and the redox at -0.06 V gradually disappears with DNA addition. At the same time, UV-spectra of Co(phen)33+ are regularly changed in the presence of 6-MP and DNA. All results indicate that the obvious interaction equilibrium is proved to exist among Co(phen)33+, 6-MP and calf thymus DNA. |
| Keywords: 6-Mercaptopurine Co(phen)33+ DNA interaction |
| |
| 摘要点击次数: 1620 |
| 全文下载次数: 1400 |
| 周翠凤,李 红,乐学义.Co(phen)33+与6-巯基嘌呤及DNA间相互作用的研究[J].无机化学学报,2004,20(1):115-118. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| Support information: |
|
|
|
|
|
|
