| 用紫外-可见吸收光谱研究微过氧化物酶-8与La3+相互作用机理 | |
| Study on Mechanism of Interaction between Microperoxidase-8 and La3+ Using UV-Vis Absorption Spectroscopy | |
| 摘要: 首次用紫外-可见(UV-Vis)吸收光谱技术研究了微过氧化物酶-8(MP-8)与La3+的相互作用的机理。发现La3+优先与MP-8分子中血红素卟啉环上的两个丙酸基团的羧基氧发生键合作用,使血红素卟啉环的非平面性增加,π-π*跃迁所需要的能量减少,但几率降低。La3+与MP-8肽链上的羰基氧发生弱相互作用,因此对卟啉环的结构基本上没有影响。 | |
| 关键词: 微过氧化物酶-8 镧离子 紫外-可见吸收光谱 | |
| 基金项目: | |
| Abstract: The mechanism of the interaction between microperoxidase-8 and La3+ was studied for the first time using UV-Vis absorption spectroscopic technique. It was found that La3+ bond firstly to carbonyl oxygen of the metace-tonic acid group in the heme group of the MP-8 molecule. It results in the increase in the non-planarity of the porphyrin group in the heme group and the decrease in the energy for the π-π* transition. However, the proba-bility of the π-π* transition is decreased. La3+ interact with carbonyl oxygen of the amido groups in the peptide of the MP-8 molecule based on the weak interaction. Therefore, it does not affect the structure of the prophyrin group. | |
| Keywords: microperoxydase-8 La3+ UV-Vis absorption spectroscopy | |
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| 陈婷婷,黄晓华,冯玉英,杜江燕,刘长鹏,邢 巍,陆天虹.用紫外-可见吸收光谱研究微过氧化物酶-8与La3+相互作用机理[J].无机化学学报,2003,19(9):941-944. | |
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