无机化学学报

改变枸橼酸和EDTA抗衡阳离子对草酸钙结石抑制作用的体外模拟

In Vitro Simulation on the Inhibition of Calcium Oxalate Calculus by Changing the Counterions of Citric Acid and EDTA

作者	单位
欧阳健明	暨南大学生物矿化与结石病防治研究所，广州 510632
谭燕华	暨南大学生物矿化与结石病防治研究所，广州 510632
邝荔	暨南大学生物矿化与结石病防治研究所，广州 510632 暨南大学医学院第一附属医院泌尿外科，广州 510632
苏泽轩	暨南大学医学院第一附属医院泌尿外科，广州 510632
粱蔚波	暨南大学生物矿化与结石病防治研究所，广州 510632 暨南大学医学院第一附属医院泌尿外科，广州 510632

摘要:

关键词: 草酸钙结石枸橼酸 EDTA 抗衡离子凝胶

基金项目:

Abstract: The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate (CaO_x) were in-vestigated in silica gel with a double diffusion technique. The ability of inhibiting the growth and aggregation of CaO_x crystal and the ability of inducing formation of COD follows： potassium citrate 》 sodium citrate >citric acid. Na₂EDTA had a stronger ability to inhibit the aggregation of CaO_x crystals than that of EDTA， but a weaker ability to inhibit nucleation and growth of CaO_x crystals. Since COM exhibits a greater degree of attachment to renal tubule cells in culture compared with COD， that is， COD is easy to be expelled from the body along with the urine. So both inducing formation of COD and inhibiting growth and aggregation of CaO_x crystal can decrease the probability of urinary stones. These results have positive significance in the prevention and cure of urinary stones clinically.

Keywords: calcium oxalate calculus citric acid EDTA counterion gel

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欧阳健明,谭燕华,邝荔,苏泽轩,粱蔚波.改变枸橼酸和EDTA抗衡阳离子对草酸钙结石抑制作用的体外模拟[J].无机化学学报,2003,19(3):312-316.

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