无机化学学报

(1R,3R)-1-氨基-1,3-二羧基环丁烷衍生物桥联环糊精与一组低分子量多肽之间的包合行为

Inclusion Behavior of the Double Cyclodextrin Bridged with (1R,3R)-1-Amino-Cyclobutane-cis-1,3-Dicarboxylic Acid Derivative to the Peptides with Low Molecular Weight

作者	单位
宋乐新	南京大学配位化学研究所,配位化学国家重点实验室,南京 210093
涂超	南京大学配位化学研究所,配位化学国家重点实验室,南京 210093
赵亮	南京大学配位化学研究所,配位化学国家重点实验室,南京 210093
郭子建	南京大学配位化学研究所,配位化学国家重点实验室,南京 210093

摘要:

关键词: 环糊精氨基酸多肽包合物分子识别

基金项目:

Abstract: The interactions between several peptides with low molecular weight (guest, NH₂-Arg-Arg-Trp-Trp-H 2; NH₂-Arg-Trp-Arg-Trp-H 3; NH₂-Trp-Arg-Arg-Trp-H 4; NH₂-Arg-Arg-Trp-Trp-Trp-Trp-H 5; NH₂-Trp-Trp-Arg-Arg- Trp-Trp-H 6; NH₂-Arg-Arg-Trp-Trp-Trp-Trp-Trp-Trp-H 7; NH₂-Arg-Arg-Trp-Trp-Trp-Trp-Trp-Trp-Trp-Trp-H 8) and β-cyclodextrin dimer (host, 1) bridged with the derivative of (1R, 3R)-1-aminocyclobutane-cis-1,3-dicar- boxylic acid were investigated by using fluorescence polarization method in buffer aqueous solution (pH 7.4) at 298K. The binding constants of the cyclodextrin dimer 1 to the guests 2-8 were determined. It was shown that there was a cooperative action of the two cavities of a cyclodextrin dimer in the binding of large substrates, and that the structure and properties of amino acid in the peptides played very important roles in the synergic complexation between host and guest.

Keywords: cyclodextrin amino acid peptide inclusion compound molecular recognition

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宋乐新,涂超,赵亮,郭子建.(1R,3R)-1-氨基-1,3-二羧基环丁烷衍生物桥联环糊精与一组低分子量多肽之间的包合行为[J].无机化学学报,2002,18(5):518-522.

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