| 九配位钬-三乙四胺六乙酸配合物K3[Ho(TTHA)]·5H2O的合成及分子结构 |
| Synthesis and Molecular Structure of Nine-Coordinate Complex K3[Ho(TTHA)]·5H2O |
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| 摘要: |
| 关键词: Ho(Ⅲ) 三乙四胺六乙酸(TTHA) 配合物 分子结构 |
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| Abstract: In this paper, the molecular and crystal structures of the K3[Ho(TTHA)]·5H2O(TTHA=triethylenete-traminehexaacetic acid)are given. The crystal data are as follows: monoclinic system, P21/c space group, a=1.0290(9)nm, b=1.2466(11)nm, c=2.279(2)nm, β=91.322(16)°, V=2.923(5)nm3, Z=4, M=860.67, Dc=1.956gcm-3, μ=3.217mm-1, F(000)=1720. The final R1 and wR2 are 0.0395 and 0.0796 for 5145 [I >2.0σ(I)] unique reflections and 0.0546 and 0.0833 for all 11567 reflections, respectively. In the title complex, the anion [Ho(TTHA)]3- has a nine-coordination structure with distorted tricapped trigonal prism. A TTHA having four N atoms of amido groups and six O atoms of carboxylic groups acts as a enneadentate ligand with four N atoms and five O atoms. In addition, there is a free non-coordinated carboxyl group (-CH2COO-) in the complex anion [Ho(TTHA)]3-. The free carboxyl group could be embellished by some biological molecules which have selectivity and affinity to tumor cell. Then the 166HoⅢ- TTHA complex may become radioactive anti-tumor drug having targeting function. |
| Keywords: Ho(Ⅲ) triethylenetetraminehexaacetic acid (TTHA) complex molecular structure |
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| 王君,领小,张向东,贾卫国,范大民.九配位钬-三乙四胺六乙酸配合物K3[Ho(TTHA)]·5H2O的合成及分子结构[J].无机化学学报,2002,18(5):509-512. |
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